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Neutralization tests performed on sera from OHFV\u2010 and TBEV\u2010infected mice showed that neutralizing antibodies are cross\u2010protective. The geometric mean titers of antibodies against TBEV and OHFV from TBEV\u2010infected mice were similar. However, the titers of anti\u2010TBEV antibodies in OHFV\u2010infected mice were significantly lower than those of anti\u2010OHFV antibodies in the same animals. In mouse vaccination and challenge tests, the TBE vaccine provided 100% protection against OHFV infection. Eighty\u2010six percent of vaccinees seroconverted against OHFV following complete vaccination, and the geometric mean titers of neutralizing antibodies against OHFV were comparable to those against TBEV. 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