{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:14:29Z","timestamp":1696572869570},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:00:00Z","timestamp":1424390400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label \/><jats:p>Toxoplasma gondii is an obligate intracellular protozoan pathogen that can cross the placenta, resulting in congenital toxoplasmosis with severe fetal brain abnormalities. The molecular mechanisms of immune responses against <jats:italic>T. gondii<\/jats:italic> infection in the placenta have largely remained unclear. An analytical method for characterizing phenotypes of immune cells in the placenta by flow cytometry was established and it was found that numbers of CD11b<jats:sup>+<\/jats:sup> Gr\u20101<jats:sup>+<\/jats:sup> cells in the placenta increased significantly after <jats:italic>T. gondii<\/jats:italic> infection. These results suggest that innate immune responses play an important role in immunity against <jats:italic>T. gondii<\/jats:italic> infection via the feto\u2010maternal interface.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12225","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T03:49:54Z","timestamp":1420429794000},"page":"95-98","source":"Crossref","is-referenced-by-count":0,"title":["Increased CD11b<sup>+<\/sup> Gr\u20101<sup>+<\/sup> cell population in the placenta after infection with <i>Toxoplasma gondii<\/i>"],"prefix":"10.1111","volume":"59","author":[{"given":"Kinuko","family":"Takeshima","sequence":"first","affiliation":[{"name":"Department of Immunology"},{"name":"Obstetrics and Gynecology Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Nabekura","sequence":"additional","affiliation":[{"name":"Department of Immunology"},{"name":"Life Science Center of Tsukuba Advanced Research Alliance"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kisaburo","family":"Nagamune","sequence":"additional","affiliation":[{"name":"Faculty of Life and Environmental Sciences"},{"name":"Department of Parasitology National Institute of Infectious Diseases Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Immunology"},{"name":"Life Science Center of Tsukuba Advanced Research Alliance"},{"name":"Japan Science and Technology Agency Core Research for Evolutional Science and Technology University of Tsukuba Ibaraki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.4.569"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.019"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00472-09"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307868110"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05730-11"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220272110"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198802043180509"},{"key":"e_1_2_4_10_1","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1128\/jcm.31.11.2952-2959.1993","article-title":"Role of specific immunoglobulin E in diagnosis of acute toxoplasma infection and toxoplasmosis","volume":"31","author":"Wong S.Y.","year":"1993","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.6.853"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2007.01.008"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3070"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1348-0421.12225","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.12225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:17:40Z","timestamp":1696483060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1348-0421.12225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/1348-0421.12225"],"URL":"https:\/\/doi.org\/10.1111\/1348-0421.12225","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"value":"0385-5600","type":"print"},{"value":"1348-0421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}