{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:28:23Z","timestamp":1778552903745,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Key Project of Science and Technology of Zhejiang Province","award":["No. 2008C03003-1"],"award-info":[{"award-number":["No. 2008C03003-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Enterovirus 71 (EV71) infection can cause severe neurological complications including meningoencephalitis (ME) in some patients with hand, foot and mouth disease (HFMD). However, to date no studies have reported changes in cytokine concentrations and their correlations with clinical variables in patients with ME following EV71 infection. In this study, responses of Th1\/Th2 cytokine, including IL\u20102, IL\u20104, IL\u20106, IL\u201010, TNF\u2010\u03b1 and IFN\u2010\u03b3, in cerebrospinal fluid (CSF) from patients with EV71\u2010related HFMD with ME and patients with febrile convulsions (FC) were analyzed using cytometric bead array technology. It was found that CSF IL\u20106 and IFN\u2010\u03b3 concentrations were significantly higher in patients with EV71\u2010related ME than in those with FC. Additionally, both CSF IL\u20106 and IFN\u2010\u03b3 concentrations were correlated with CSF cytology, fever duration and duration of hospital stay. More interestingly, a positive correlation between CSF IL\u20106 and IFN\u2010\u03b3 concentrations was observed. Finally, receiver operating characteristic analysis revealed that when a cutoff value of 9.40\u2009pg\/mL was set for IL\u20106, the sensitivity and specificity were 84.5% and 85.5%, respectively, for discriminating EV71\u2010related ME from FC. In conclusion, IL\u20106 and IFN\u2010\u03b3 may be associated with EV71\u2010induced neuropathology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12227","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T10:58:55Z","timestamp":1421924335000},"page":"152-159","source":"Crossref","is-referenced-by-count":18,"title":["Cerebrospinal fluid Th1\/Th2 cytokine profiles in children with enterovirus 71\u2010associated meningoencephalitis"],"prefix":"10.1111","volume":"59","author":[{"given":"Huajun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pulmonology Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang  310003,"},{"name":"Department of Pediatrics Shaoxing People's Hospital Shaoxing Zhejiang 312000"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang  310003,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Maternal and Child Care Service Centre Cixi Ningbo Zhejiang 315300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang  310003,"},{"name":"Department of Infectious Disease Hangzhou Children's Hospital Hangzhou Zhejiang 310014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Taizhou Central Hospital Jiaojiang Taizhou Zhejiang 318000"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease First Affiliated Hospital Zhejiang University Hangzhou Zhejiang 310013"},{"name":"Department of Toxicology Hangzhou Normal University School of Public Health Hangzhou Zhejiang  310016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang  310003,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00563-09"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2002.tb00601.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/314032"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411301"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02879323"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/383787a0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.4049\/jimmunol.146.2.592","article-title":"Tumor necrosis factor combines with IL\u20104 or IFN\u2010gamma to selectively enhance endothelial cell adhesiveness for T cells. 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