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Microbial infection and dysimmunity appear to play important roles in its pathogenesis. In this study, differences in genetic profiling of salivary microbial communities in two subtypes of OLP and healthy controls were evaluated by means of PCR\u2010denaturing gradient gel electrophoresis (DGGE). Additionally, ELISA was used to investigate the possible role of Th17 in lesion formation by detecting two related cytokines IL\u201017 and IL\u201023 in the saliva of OLP patients. When the DGGE profiles were analyzed, the bacterial populations were found to be significantly less rich in subjects with reticular and erosive OLP than in healthy controls. There was significantly less microbial diversity, as denoted by the Shannon index, in saliva samples from subjects with erosive OLP than in those from healthy controls. Cluster analysis and principal component analysis showed that the DGGE profiles formed distinctly group\u2010specific clusters. Salivary concentrations of IL\u201017 in subjects with erosive OLP group were significantly higher than in those with reticular OLP and healthy controls. What's more, significantly positive correlations were observed between salivary IL\u201017 concentrations and disease clinical scores. Microbial richness and diversity was negatively correlated with salivary IL\u201017 concentrations. These results suggest there is significantly less salivary bacterial diversity and complexity in subjects with OLP han in healthy controls and that the shifted community composition is closely related to an immune cytokine, IL\u201017.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12232","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T10:08:51Z","timestamp":1422958131000},"page":"105-113","source":"Crossref","is-referenced-by-count":48,"title":["Analysis of oral microbial community and Th17\u2010associated cytokines in saliva of patients with oral lichen planus"],"prefix":"10.1111","volume":"59","author":[{"given":"Kun","family":"Wang","sequence":"first","affiliation":[{"name":"State Key L aboratory  of Oral Diseases West China Hospital of Stomatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Miao","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key L aboratory  of Oral Diseases West China Hospital of Stomatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhi","family":"He","sequence":"additional","affiliation":[{"name":"State Key L aboratory  of Oral Diseases West China Hospital of Stomatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomiao","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key L aboratory  of Oral Diseases West China Hospital of Stomatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key L aboratory  of Oral Diseases West China Hospital of Stomatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key L aboratory  of Oral Diseases West China Hospital of Stomatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key L aboratory  of Oral Diseases West China Hospital of Stomatology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.076"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2002.tb00540.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300503"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5721-5732.2005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.077"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90013-T"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900110"},{"key":"e_1_2_7_9_1","first-page":"209","article-title":"Oral lichen planus and liver pathology. 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