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Here, the aim was to determine the expression and role of TLR2 in peripheral blood mononuclear cells (PBMCs) from patients with cryptococcal meningitis and healthy controls. TLR2 expression was measured using RT\u2010PCR and western blotting. The role of TLR2 in cytokine production by PBMCs after <jats:italic>Cryptococcus neoformans<\/jats:italic> exposure was assessed in healthy controls prior to incubation with anti\u2010TLR2. TLR2 mRNA and protein expression were both weaker in patients with cryptococcal meningitis than in healthy controls. Furthermore, pre\u2010incubation of PBMCs from healthy donors with anti\u2010TLR2 led to reduced expression of IFN\u2010\u03b3 and IL\u201012p70, but not of IL\u20104 and IL\u201010, following <jats:italic>C. neoformans<\/jats:italic> stimulation. Our results suggest that impaired expression of TLR2 may be involved in defective host defense to <jats:italic>C. neoformans<\/jats:italic> through an attenuated Th1 response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12264","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T04:59:39Z","timestamp":1431061179000},"page":"357-364","source":"Crossref","is-referenced-by-count":3,"title":["Decreased TLR2 signal expression in peripheral blood mononuclear cell from patients with cryptococcal meningitis"],"prefix":"10.1111","volume":"59","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Laboratory Diagnosis, Changhai Hospital Second Military Medical University 168 Changhai Road Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnosis, Changhai Hospital Second Military 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