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Plasma concentrations of matricellular proteins were studied to determine their diagnostic value as potential markers of tuberculosis (TB) activity. It was found that concentrations of OPN and TN\u2010C were higher in patients with active TB than in healthy controls and individuals with latent infection. Moreover, LTBI patients had higher concentrations of OPN than did healthy controls. Gal\u20109 concentrations did not differ significantly between groups. Concentrations of matricellular proteins were higher in pleural fluid than in the plasma of patients with TB. Expression of matricellular proteins was also investigated in TB granulomas and other granulomatous diseases. Positive OPN and Gal\u20109 staining was observed in TB and sarcoidosis granulomas, but not in Crohn disease granulomas. The fibrotic ring around granulomas stained positive for TN\u2010C in TB and sarcoidosis, but not in Crohn disease. Of the three matricellular proteins studied, OPN and TN\u2010C may serve as reliable plasma markers for monitoring TB activity, whereas Gal\u20109 seems to be expressed more at the site of infection than in the systemic circulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12320","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T06:42:01Z","timestamp":1441348921000},"page":"623-632","source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of matricellular proteins in systemic and local immune response to <i>Mycobacterium tuberculosis<\/i> infection"],"prefix":"10.1111","volume":"59","author":[{"given":"Fakhrial Mirwan","family":"Hasibuan","sequence":"first","affiliation":[{"name":"Division of Emerging Infectious Diseases Graduate School of Medicine Tohoku University"},{"name":"Public Health Science Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Shiratori","sequence":"additional","affiliation":[{"name":"Division of Emerging Infectious Diseases Graduate School of Medicine Tohoku University"},{"name":"Division of Disaster\u2010related Infectious Diseases International Research Institute of Disaster Science Tohoku University 2\u20101 Seiryo\u2010machi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Andrian","family":"Senoputra","sequence":"additional","affiliation":[{"name":"Division of Emerging Infectious Diseases Graduate School of Medicine Tohoku University"},{"name":"Public Health Science Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haorile","family":"Chagan\u2010Yasutan","sequence":"additional","affiliation":[{"name":"Division of Emerging Infectious Diseases Graduate School of Medicine Tohoku University"},{"name":"Division of Disaster\u2010related Infectious Diseases International Research Institute of Disaster Science Tohoku University 2\u20101 Seiryo\u2010machi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raspati Cundarani","family":"Koesoemadinata","sequence":"additional","affiliation":[{"name":"TB\u2010HIV Research Center Faculty of Medicine Padjadjaran University Jl Eicjkman 38 Bandung 40161 West Java Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lika","family":"Apriani","sequence":"additional","affiliation":[{"name":"TB\u2010HIV Research Center Faculty of Medicine Padjadjaran University Jl Eicjkman 38 Bandung 40161 West Java Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayoi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Tohoku University Hospital 1\u20101 Seiryo\u2010machi, Aoba\u2010ku Sendai 980\u20108574 Miyagi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Niki","sequence":"additional","affiliation":[{"name":"Research Division GalPharma Company NEXT\u2010Kagawa 204, 2217\u201044 Hayashi\u2010cho Takamatsu\u2010shi Kagawa 760\u20100301 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bachti","family":"Alisjahbana","sequence":"additional","affiliation":[{"name":"TB\u2010HIV Research Center Faculty of Medicine Padjadjaran University Jl Eicjkman 38 Bandung 40161 West Java Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Hattori","sequence":"additional","affiliation":[{"name":"Division of Emerging Infectious Diseases Graduate School of Medicine Tohoku University"},{"name":"Public Health Science Program"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.Global tuberculosis report2013. 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