{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:22:02Z","timestamp":1765887722850,"version":"3.41.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Previous studies using experimental animal models have reported the beneficial effects of probiotics on allergic responses; however, their long\u2010term effects on allergic nasal symptoms in clinical settings have not yet been elucidated in detail. In the present study, a guinea pig allergic rhinitis model involving repeated inhalation challenges with a natural allergen, Japanese cedar pollen, was used to examine the longitudinal effects of<jats:italic>Bifidobacterium bifidum<\/jats:italic>G9\u20101 (BBG9\u20101) on allergic nasal symptoms. BBG9\u20101 was administered orally once a day. Amelioration of nasal blockage was consistently observed throughout the experimental period in the BBG9\u20101\u2010treated group. Although challenge\u2010induced sneezing was not significantly inhibited in the BBG9\u20101\u2010treated group, prolonged treatment with BBG9\u20101 slightly reduced the frequency of sneezing. Antigen\u2010specific IgE antibody production was also not inhibited in the BBG9\u20101\u2010treated group. Increases in the numbers of eosinophils and neutrophils in nasal cavity lavage fluid collected after pollen challenge were almost completely suppressed by BBG9\u20101 treatment, whereas those in mast cell mediators, histamine and cysteinyl leukotrienes were not. In contrast, increases in the levels of nitric oxide metabolites were potently suppressed. Furthermore, prolonged BBG9\u20101 treatment markedly suppressed exogenous leukotriene D<jats:sub>4<\/jats:sub>\u2010induced nasal blockage. Thus, prolonged oral administration of BBG9\u20101 suppresses Japanese cedar pollen\u2010induced allergic nasal symptoms. The inhibitory mechanisms responsible may involve reductions in the responsiveness of target organs, such as endothelial cells in nasal mucosal blood vessels, to chemical mediators.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12324","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T08:20:59Z","timestamp":1443082859000},"page":"690-699","source":"Crossref","is-referenced-by-count":7,"title":["Longitudinal study of effects of oral dosage of<i>Bifidobacterium bifidum<\/i>G9\u20101 on Japanese cedar pollen\u2010induced allergic nasal symptoms in guinea pigs"],"prefix":"10.1111","volume":"59","author":[{"given":"Satoru","family":"Tsunemine","sequence":"first","affiliation":[{"name":"Biofermin Kobe Research institute Biofermin Pharmaceutical Co., Ltd. 7\u20103\u20104 Ibukidai\u2010Higashimachi, Nishi\u2010ku Kobe 651\u20102242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Isa","sequence":"additional","affiliation":[{"name":"Biofermin Kobe Research institute Biofermin Pharmaceutical Co., Ltd. 7\u20103\u20104 Ibukidai\u2010Higashimachi, Nishi\u2010ku Kobe 651\u20102242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohno","sequence":"additional","affiliation":[{"name":"Biofermin Kobe Research institute Biofermin Pharmaceutical Co., Ltd. 7\u20103\u20104 Ibukidai\u2010Higashimachi, Nishi\u2010ku Kobe 651\u20102242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Hagino","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kyoto Pharmaceutical University 5 Nakauchi, Misasagi, Yamashina Kyoto 607\u20108414"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Yamamura","sequence":"additional","affiliation":[{"name":"Biofermin Kobe Research institute Biofermin Pharmaceutical Co., Ltd. 7\u20103\u20104 Ibukidai\u2010Higashimachi, Nishi\u2010ku Kobe 651\u20102242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kobe Pharmaceutical University 4\u201019\u20101 Motoyama\u2010kita, Higashinada Kobe 658\u20108558 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nabe","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology Faculty of Pharmaceutical Sciences Setsunan University 45\u20101 Nagaotoge\u2010cho, Hirakata Osaka 573\u20100101"},{"name":"Department of Pharmacology Kyoto Pharmaceutical University 5 Nakauchi, Misasagi, Yamashina Kyoto 607\u20108414"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115754"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47306-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2005466"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12174"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.2163"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2007.tb04006.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.1462"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/S0022-3565(24)36539-5","article-title":"Involvement of thromboxane A2 and histamine in experimental allergic rhinitis of guinea pigs","volume":"280","author":"Yamasaki M.","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000237487"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050346"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.12938\/bifidus.30.1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","unstructured":"Bousquet J. Khaltaev N. Cruz A.A. Denburg J. Fokkens W.J. Togias A. Zuberbier T. Baena\u2010Cagnani C.E. Canonica G.W. van Weel C. Agache I. A\u00eft\u2010Khaled N. Bachert C. Blaiss M.S. Bonini S. Boulet L.P. Bousquet P.J. Camargos P. Carlsen K.H. Chen Y. Custovic A. Dahl R. Demoly P. Douagui H. Durham S.R. van Wijk R.G. Kalayci O. Kaliner M.A. Kim Y.Y. Kowalski M.L. Kuna P. Le L.T. Lemiere C. Li J. Lockey R.F. Mavale\u2010Manuel S. Meltzer E.O. Mohammad Y. Mullol J. Naclerio R. O'Hehir R.E. Ohta K. Ouedraogo S. Palkonen S. Papadopoulos N. Passalacqua G. Pawankar R. Popov T.A. Rabe K.F. Rosado\u2010Pinto J. Scadding G.K. Simons F.E. Toskala E. Valovirta E. van Cauwenberge P. Wang D.Y. Wickman M. Yawn B.P. Yorgancioglu A. Yusuf O.M. Zar H. Annesi\u2010Maesano I. Bateman E.D. Ben Kheder A. Boakye D.A. Bouchard J. Burney P. Busse W.W. Chan\u2010Yeung M. Chavannes N.H. Chuchalin A. Dolen W.K. Emuzyte R. Grouse L. Humbert M. Jackson C. Johnston S.L. Keith P.K. Kemp J.P. Klossek J.M. Larenas\u2010Linnemann D. Lipworth B. Malo J.L. Marshall G D. Naspitz C. Nekam K. Niggemann B. Nizankowska\u2010Mogilnicka E. Okamoto Y. Orru M.P. Potter P. Price D. Stoloff S.W. Vandenplas O. Viegi G. Williams D. (2008) Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization GA(2)LEN and AllerGen).Allergy63(Suppl 86): 8\u2013160.","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2011.1.3.157"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.75.243"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14613689"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.86.170"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.46.2.399"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0050372"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000272"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000273"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)82012-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.51.581"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(98)75549-3"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.O-06-459"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2010.2.3.199"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)02188-5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01042-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.011"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/321241"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1109753"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.12938\/bmfh.32.81"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1348-0421.12324","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.12324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T19:54:52Z","timestamp":1748634892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1348-0421.12324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/1348-0421.12324"],"URL":"https:\/\/doi.org\/10.1111\/1348-0421.12324","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"type":"print","value":"0385-5600"},{"type":"electronic","value":"1348-0421"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}