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In addition, PcrV, a component protein of the TTSS, has been characterized as a protective antigen against infection with <jats:italic>P. aeruginosa<\/jats:italic>. This study comprised an epidemiological analysis of serum anti\u2010PcrV titers in a cohort of Japanese adults. From April 2012 to March 2013, serum anti\u2010PcrV titers of 198 volunteer participants undergoing anesthesia for scheduled surgeries were measured. The median, minimum and maximum serum anti\u2010PcrV titers among the 198 participants were 4.09\u2009nM, 1.01\u2009nM and 113.81\u2009nM, respectively. The maximum peaks in the histogram were within the anti\u2010PcrV 2.00\u20134.99\u2009nM titer range; values for 115 participants (58.1%) were within this range. Anti\u2010PcrV titers were more than approximately three\u2010fold greater (&gt;12\u2009nM) than the median value in 21 participants (10.6%). Ten\u2010year interval age increases, history of treatment for traffic trauma, and a history of past surgery each showed statistically significant associations with higher anti\u2010PcrV titers (i.e., &gt;10\u2009nM) than did the other factors assessed by binomial analysis. This study revealed a considerable variation in anti\u2010PcrV titers in adult subjects without any obvious histories of infection with <jats:italic>P. aeruginosa<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12353","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T08:21:25Z","timestamp":1450858885000},"page":"114-120","source":"Crossref","is-referenced-by-count":7,"title":["Epidemiological analysis of serum anti\u2010<i>Pseudomonas aeruginosa<\/i> PcrV titers in adults"],"prefix":"10.1111","volume":"60","author":[{"given":"Hiroaki","family":"Yasumoto","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Kyoto Prefectural University of Medicine Kyoto 602\u20108566 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kyoto Prefectural University of Medicine Kyoto 602\u20108566 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kyoto Prefectural University of Medicine Kyoto 602\u20108566 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kyoto Prefectural University of Medicine Kyoto 602\u20108566 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeko","family":"Hamaoka","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kyoto Prefectural University of Medicine Kyoto 602\u20108566 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kyoto Prefectural University of Medicine Kyoto 602\u20108566 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kyoto Prefectural University of Medicine Kyoto 602\u20108566 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teiji","family":"Sawa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kyoto Prefectural University of Medicine Kyoto 602\u20108566 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.2.2.15014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp255"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2015.08.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7124"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2199"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2052-0492-2-10"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.6251991.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1427-5_10"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg290"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04194.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01939.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042973"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0668-9"},{"key":"e_1_2_8_15_1","first-page":"129","article-title":"The basis of virulence in Pasteurella pestis: attempts to induce mutation from avirulence to virulence","volume":"35","author":"Burrows T.W.","year":"1954","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/177426b0"},{"key":"e_1_2_8_17_1","first-page":"481","article-title":"The basis of virulence in Pasteurella pestis: An antigen determining virulence","volume":"37","author":"Burrows T.W.","year":"1956","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_8_18_1","first-page":"278","article-title":"The effects of loss of virulence determinants on the virulence and immunogenicity of strains of Pasteurella pestis","volume":"39","author":"Burrows T.W.","year":"1958","journal-title":"Brit J Exp Pathol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/j.1749-6632.1960.tb20102.x","article-title":"W. 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