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Amounts of JEV RNA and E protein were significantly smaller in p62\u2010deficient cells than wild\u2010type cells at 24 hr post\u2010infection (p.i.). JEV RNA quantitation and viral plaque assays showed significant reductions in viral titers in p62\u2010deficient cell culture fluid. Our results indicate that JEV replication is impaired in p62\u2010deficient MEFs, suggesting that p62 positively regulates JEV replication in host cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12440","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T11:52:53Z","timestamp":1473853973000},"page":"708-711","source":"Crossref","is-referenced-by-count":11,"title":["Impaired Japanese encephalitis virus replication in p62\/SQSTM1 deficient mouse embryonic fibroblasts"],"prefix":"10.1111","volume":"60","author":[{"given":"Takafumi","family":"Tasaki","sequence":"first","affiliation":[{"name":"Division of Protein Regulation Research, Department of Life Science, Medical Research Institute Kanazawa Medical University 1\u20101 Daigaku, Uchinada, Kahoku\u2010gun Ishikawa 920\u20100293 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Nukuzuma","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Kobe Institute of Health 4\u20106\u20105, Minatojima\u2010Nakamachi Chuo\u2010ku Kobe 650\u20100046 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takegami","sequence":"additional","affiliation":[{"name":"Department of Life Science Medical Research Institute, Kanazawa Medical University 1\u20101 Daigaku, Uchinada Kahoku\u2010gun Ishikawa 920\u20100293 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00403-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13540"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2011.09.001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29455"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(98)00130-0"},{"key":"e_1_2_5_8_1","unstructured":"LindenbachB.D. 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