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Here, the cross\u2010reactivity and cross\u2010protectivity of mAbs against <jats:italic>V. vulnificus<\/jats:italic> RtxA1\/MARTX<jats:sub>Vv<\/jats:sub> was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal <jats:italic>V. cholerae<\/jats:italic> infection. Interestingly, 24RA and 46RA, which map to the cysteine protease domain of <jats:italic>V. cholerae<\/jats:italic> MARTX<jats:sub>Vc<\/jats:sub>, inhibited CPD autocleavage <jats:italic>in vitro<\/jats:italic>; this process is involved in <jats:italic>V. cholerae<\/jats:italic> pathogenesis. These results generate new insight into the development of broadly protective mAbs and\/or vaccines against <jats:italic>Vibrio<\/jats:italic> species with MARTX toxins.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12449","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T07:40:07Z","timestamp":1478504407000},"page":"793-800","source":"Crossref","is-referenced-by-count":0,"title":["Cross\u2010protection against <i>Vibrio cholerae<\/i> infection by monoclonal antibodies against <i>Vibrio vulnificus<\/i> RtxA1\/MARTX<sub>Vv<\/sub>"],"prefix":"10.1111","volume":"60","author":[{"given":"Tae Hee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Chonbuk National University Medical School Jeonju Jeonbuk 54896 Republic of Korea"},{"name":"Institute for Medical Science Chonbuk National University Medical School Jeonju Jeonbuk 54896 Republic of 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