{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:18:52Z","timestamp":1783477132691,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["16K08384"],"award-info":[{"award-number":["16K08384"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The common skin disease acne vulgaris is caused by <jats:italic>Propionibacterium acnes<\/jats:italic>. A lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. The antifungal drug ketoconazole inhibits <jats:italic>P. acnes<\/jats:italic> lipase activity. We previously showed that the drug also inhibits the growth of <jats:italic>P. acnes<\/jats:italic>. Thus, ketoconazole may serve as an alternative treatment for acne vulgaris, which is important because the number of antibiotic\u2010resistant <jats:italic>P. acnes<\/jats:italic> strains has been increasing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12464","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T05:46:37Z","timestamp":1485150397000},"page":"42-44","source":"Crossref","is-referenced-by-count":23,"title":["Inhibition of <i>Propionibacterium acnes<\/i> lipase activity by the antifungal agent ketoconazole"],"prefix":"10.1111","volume":"61","author":[{"given":"Mizuki","family":"Unno","sequence":"first","affiliation":[{"name":"Department of Microbiology Meiji Pharmaceutical University 2\u2010522\u20101 Noshio Kiyose Tokyo 204\u20108588 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otomi","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Microbiology Meiji Pharmaceutical University 2\u2010522\u20101 Noshio Kiyose Tokyo 204\u20108588 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Microbiology Meiji Pharmaceutical University 2\u2010522\u20101 Noshio Kiyose Tokyo 204\u20108588 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.005"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-230"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12252"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S69135"},{"key":"e_1_2_5_6_1","article-title":"Acne vulgaris","author":"Purdy S.","year":"2011","journal-title":"BMJ Clin Evid"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00527-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12989"},{"key":"e_1_2_5_9_1","first-page":"1805","article-title":"The effects of vitamins on the growth and lipase activity of Propionibacterium acnes","volume":"115","author":"Niki K.","year":"2005","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.150364"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00706.x"},{"key":"e_1_2_5_12_1","first-page":"259","article-title":"Inhibition of sebum production and Propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: potential as a therapeutic reagent for acne","volume":"63","author":"Inui S.","year":"2012","journal-title":"J Cosmet Sci"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.125"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13245"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12586"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01721288"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1300333"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-2-335"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1003337"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1348-0421.12464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.12464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:44:53Z","timestamp":1696178693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1348-0421.12464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/1348-0421.12464"],"URL":"https:\/\/doi.org\/10.1111\/1348-0421.12464","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"value":"0385-5600","type":"print"},{"value":"1348-0421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}