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Its 50% effective concentration against the cell\u2010free vaccine Oka strain and 50% cytotoxic concentration in human fibroblasts were 16.9\u2009\u00b5M and more than 100\u2009\u00b5M, respectively. Treatment with 45B5 decreased viral DNA synthesis and IE62 expression weakly but significantly. All 45B5\u2010resistant viral clones isolated were found to have at least one mutation in ORF54 that encodes the portal protein. There were no effects on interaction between the portal and scaffold proteins. 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