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The crucial roles of IgM and IgZ in imparting systemic and mucosal immunity, respectively, in various fish species have been widely established. However, the putative function of a unique IgD isotype during pathogenic invasions has not been well explored. The present study reports the existence of an IgD ortholog in freshwater carp, <jats:italic>Catla catla,<\/jats:italic> and further evaluates its differential expression profile in response to bacterial, parasitic and viral antigenic exposure and pathogen associated molecular patterns (PAMPs) stimulation. The IgD of <jats:italic>C. catla<\/jats:italic> (<jats:italic>Cc<\/jats:italic>IgD) cDNA sequence was found to encode 226 amino acids and confirmed homology with heavy chain delta region of <jats:italic>Cyprinidae<\/jats:italic> family members. Phylogenetic analysis of <jats:italic>Cc<\/jats:italic>IgD exhibited greatest similarity with <jats:italic>Ctenopharyngodon idella<\/jats:italic>. qRT\u2010PCR analysis revealed significant upregulation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) of IgD gene expression in kidney with respect to other tissues at 24 hr post\u2010<jats:italic>Aeromonas hydrophila<\/jats:italic> challenge. <jats:italic>Cc<\/jats:italic>IgD gene expression in skin was enhanced following <jats:italic>Streptococcus uberis<\/jats:italic> infection and in blood following <jats:italic>Argulus<\/jats:italic> infection and inactivated rhabdoviral antigen stimulation. Further, the treatment of bacterial and viral products (PAMPs) also triggered significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) increases in <jats:italic>Cc<\/jats:italic>IgD mRNA expression in kidney. These findings indicate the functional importance of teleost IgD in orchestrating tissue specific neutralization of antigens on stimulation with different pathogens and PAMPs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12534","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T16:44:40Z","timestamp":1504716280000},"page":"452-458","source":"Crossref","is-referenced-by-count":21,"title":["Molecular cloning, characterization and expression of immunoglobulin D on pathogen challenge and pathogen associated molecular patterns stimulation in freshwater carp, <i>Catla catla<\/i>"],"prefix":"10.1111","volume":"61","author":[{"given":"Rajanya","family":"Banerjee","sequence":"first","affiliation":[{"name":"Laboratory of Environmental Microbiology and Ecology Department of Life Science National Institute of Technology Rourkela 769008"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhakti","family":"Patel","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Microbiology and Ecology Department of Life Science National Institute of Technology Rourkela 769008"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhubanti","family":"Basu","sequence":"additional","affiliation":[{"name":"Fish Health Management Division Central Institute of Freshwater Aquaculture Kausalyaganga, Bhubaneswar 751002 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saswati S.","family":"Lenka","sequence":"additional","affiliation":[{"name":"Fish Health Management Division Central Institute of Freshwater Aquaculture Kausalyaganga, Bhubaneswar 751002 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahismita","family":"Paicha","sequence":"additional","affiliation":[{"name":"Fish Health Management Division Central Institute of Freshwater Aquaculture Kausalyaganga, Bhubaneswar 751002 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal","family":"Samanta","sequence":"additional","affiliation":[{"name":"Fish Health Management Division Central Institute of Freshwater Aquaculture Kausalyaganga, Bhubaneswar 751002 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surajit","family":"Das","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Microbiology and Ecology Department of Life Science National Institute of Technology Rourkela 769008"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4593"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.121.1.185"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/252600a0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231606"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00006-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1166"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500027102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12399"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.06.441"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000631"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1999.00583.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050644"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-4648(02)00139-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-004-0693-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-005-0015-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2010.06.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101938"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2016.08.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030348"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01259.x"},{"key":"e_1_2_8_22_1","unstructured":"Food and Agriculture Organization of the United Nations Fisheries and Aquaculture Department (2006).Cultured Aquatic Species Information Programme Catla catla (Hamilton 1822). 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