{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:11:02Z","timestamp":1780704662807,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Heterologous secondary infections are at increased risk of developing dengue hemorrhagic fever (DHF) because of antibody\u2010dependent enhancement (ADE). IgG subclasses can fix and activate complement and bind to Fc\u0263 receptors. These factors may also play an important role in the development of ADE and thus in the pathogenesis of DHF. The aim of this study was to analyze the indices of anti\u2010dengue IgG subclasses in adult patients with febrile and hemorrhagic dengue in the acute phase. In 2013, 129 patients with dengue fever (DF) and 57 with DHF in Veracruz, Mexico were recruited for this study and anti\u2010dengue IgM and IgG determined by capture ELISA. Anti\u2010dengue IgG subclasses were detected by indirect ELISA. Anti\u2010dengue IgG2 and IgG3 subclasses were detected in patients with dengue. IgG1 increased significantly in the sera of patients with both primary and secondary infections and DHF, but was higher in patients with secondary infections. The IgG4 subclass index was significantly higher in the sera of patients with DHF than in that of those with DF, who were in the early and late acute phase of both primary and secondary infection. In conclusion, indices of subclasses IgG1 and IgG4 were higher in patients with DHF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12536","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T19:19:22Z","timestamp":1504811962000},"page":"433-441","source":"Crossref","is-referenced-by-count":8,"title":["Indices of anti\u2010dengue immunoglobulin G subclasses in adult Mexican patients with febrile and hemorrhagic dengue in the acute phase"],"prefix":"10.1111","volume":"61","author":[{"given":"Araceli","family":"Posadas\u2010Mondrag\u00f3n","sequence":"first","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional Plan de San Luis, Colonia Casco de Santo Tomas Mexico City 11340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Leopoldo","family":"Aguilar\u2010Faisal","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional Plan de San Luis, Colonia Casco de Santo Tomas Mexico City 11340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Ch\u00e1vez\u2010Negrete","sequence":"additional","affiliation":[{"name":"Departamento de Educaci\u00f3n y Ense\u00f1anza Hospital de Especialidades, Centro M\u00e9dico Nacional siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores Mexico City 06720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Guill\u00e9n\u2010Salom\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Educaci\u00f3n y Ense\u00f1anza,  Unidad de Medicina Familiar No. 61, Instituto Mexicano del Seguro Social Salvador D\u00edaz Mir\u00f3n, Colonia Fraccionamiento Floresta Veracruz 91940"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Alc\u00e1ntara\u2010Farf\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional Plan de Ayala, Colonia Casco de Santo Tomas Mexico City 11340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucero","family":"Luna\u2010Rojas","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional Plan de San Luis, Colonia Casco de Santo Tomas Mexico City 11340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Marineth","family":"\u00c1vila\u2010Trejo","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina de Conservaci\u00f3n, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional Plan de San Luis, Colonia Casco de Santo Tomas Mexico City 11340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"del Carmen Pacheco\u2010Y\u00e9pez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional,  Plan de San Luis, Colonia Casco de Santo Tomas Mexico City 11340 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-20-75"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05291"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61687-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/528805"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.1.201"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(03)60011-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.03.018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.09.024"},{"key":"e_1_2_8_10_1","unstructured":"MeulenbroekA.J.(2008)Human IgG Subclasses. 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