{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:01:24Z","timestamp":1777348884584,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007830","name":"Kitasato University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Culture supernatants of <jats:italic>Bordetella pertussis<\/jats:italic> are a brilliant yellow; however, the structure and biological role of the responsible pigment have not been investigated. In this study, a brilliant yellow\u2010colored fraction was extracted from culture supernatants of <jats:italic>B. pertussis<\/jats:italic> and analyzed by HPLC. UV\u2013visible spectral analysis and mass spectrometry identified the brilliant yellow pigment as riboflavin. Riboflavin production was high in lag and early log phases and riboflavin was found to enhance growth of <jats:italic>B. pertussis<\/jats:italic> in low\u2010density cultures. Riboflavin production is not regulated by the BvgAS system. In addition, it was found that other <jats:italic>Bordetella<\/jats:italic> species, such as <jats:italic>B. parapertussis<\/jats:italic>, <jats:italic>B. holmesii<\/jats:italic> and <jats:italic>B. bronchiseptica,<\/jats:italic> also release riboflavin into their culture supernatants. This is the first report that <jats:italic>B. pertussis<\/jats:italic> secrets riboflavin to the extracellular space and that riboflavin may promote its growth. The mechanism may be associated with pathogenesis of <jats:italic>B. pertussis<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12541","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T11:46:40Z","timestamp":1505389600000},"page":"490-496","source":"Crossref","is-referenced-by-count":8,"title":["Identification and characterization of a brilliant yellow pigment produced by <i>Bordetella pertussis<\/i>"],"prefix":"10.1111","volume":"61","author":[{"given":"Keita","family":"Odanaka","sequence":"first","affiliation":[{"name":"Graduate School of Infection Control Sciences 5\u20109\u20101 Shirokane Minato\u2010ku Tokyo 108\u20108641 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Iwatsuki","sequence":"additional","affiliation":[{"name":"Graduate School of Infection Control Sciences 5\u20109\u20101 Shirokane Minato\u2010ku Tokyo 108\u20108641 Japan"},{"name":"Research Center for Tropical Diseases Kitasato Institute for Life Sciences 5\u20109\u20101 Shirokane Minato\u2010ku Tokyo 108\u20108641 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomitsu","family":"Satho","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Microbiology Laboratory Fukuoka University 8\u201019\u20101 Nanakuma Jonan\u2010ku Fukuoka 814\u20100180 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-3353","authenticated-orcid":false,"given":"Mineo","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Graduate School of Infection Control Sciences 5\u20109\u20101 Shirokane Minato\u2010ku Tokyo 108\u20108641 Japan"},{"name":"Laboratory of Medical Microbiology, Kitasato Institute for Life Sciences Kitasato University 5\u20109\u20101 Shirokane Minato\u2010ku Tokyo 108\u20108641 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.2.326-382.2005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.3.480"},{"key":"e_1_2_8_4_1","unstructured":"World Health Organization.Disease incidence.2015. 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