{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:27:13Z","timestamp":1781108833475,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sichuan Science and Technology Plan Project","award":["2014SZ0002-12"],"award-info":[{"award-number":["2014SZ0002-12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The goal of this study was explore the role of indoleamine 2, 3\u2010dioxygenase (IDO) in the therapeutic effect of probiotics on inflammatory bowel disease (IBD). Trinitrobenzene sulfonic acid (TNBS) was used to induce colitis in mice and 1\u2010methyltryptophan (1\u2010MT) to block expression of IDO. Clinical manifestations and macroscopic and microscopic colonic changes were assessed using a disease activity index (DAI), the Wallace\u2013Keenan, and Curtner scoring systems, respectively. Expression of colonic IDO was detected by western blot. Immunohistochemistry analysis to evaluate numbers of CD11c<jats:sup>+<\/jats:sup> cells and expression of IL\u201017 and Foxp3 showed that DAI, Wallace\u2013Keenan, and Curtner scores were lower in the <jats:italic>Bifidobacteria<\/jats:italic> treatment group than the control group and that the therapeutic effect of <jats:italic>Bifidobacteria<\/jats:italic> was blocked by 1\u2010MT (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.05). Additionally, <jats:italic>Bifidobacteria<\/jats:italic> were found to increase expression of IDO and the numbers of CD11c<jats:sup>+<\/jats:sup> cells, CD11c<jats:sup>+<\/jats:sup> and IDO double positive cells and Foxp3<jats:sup>+<\/jats:sup> Treg cells, while decreasing the number of IL\u201017<jats:sup>+<\/jats:sup>cells (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.05). The generation of Foxp3<jats:sup>+<\/jats:sup> Treg cells induced by <jats:italic>Bifidobacteria<\/jats:italic> was abrogated by 1\u2010MT (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.05). These findings study suggest that <jats:italic>Bifidobacteria<\/jats:italic> attenuate TNBS\u2010induced colitis by inducing expression of IDO, which further increases generation of Foxp3<jats:sup>+<\/jats:sup> Treg cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12562","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T06:13:06Z","timestamp":1512972786000},"page":"71-79","source":"Crossref","is-referenced-by-count":15,"title":["<i>Bifidobacteria<\/i> alleviate experimentally induced colitis by upregulating indoleamine 2, 3\u2010dioxygenase expression"],"prefix":"10.1111","volume":"62","author":[{"given":"Li","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology West China Hospital of Sichuan University 37 Guoxue Street Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangzhen","family":"Suolang","sequence":"additional","affiliation":[{"name":"Department 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