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The nucleotide sequence of porcine circovirus\u2010like virus P1 shares high homology with open reading frame (ORF) 2 of PCV2, and ORF1 of P1 encodes its structural protein. Mice were vaccinated twice intramuscularly with a plasmid expressing the P1 ORF1 protein (pcDNA3.1(+)\u2010ORF1) at 2\u2010week intervals. All animals vaccinated with pcDNA3.1(+)\u2010ORF1 developed higher specific anti\u2010P1 antibody levels, and had less PCV2 viremia and milder histopathological changes than PCV2\u2010challenged mice in the control group. Our results show that the P1 DNA vaccine elicited immune responses against PCV2 infection in a mouse model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12571","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T07:44:53Z","timestamp":1515570293000},"page":"195-199","source":"Crossref","is-referenced-by-count":3,"title":["Protective efficacy of a DNA vaccine encoding capsid protein of porcine circovirus\u2010like virus P1 against porcine circovirus 2 in mice"],"prefix":"10.1111","volume":"62","author":[{"given":"Dan","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture National Center for Engineering Research of Veterinary Bio\u2010products Nanjing 210000 China"},{"name":"College of Veterinary Medicine Nanjing Agricultural University Nanjing 210014 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kongwang","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture National Center for Engineering Research of Veterinary Bio\u2010products Nanjing 210000 China"},{"name":"Jiangsu Co\u2010innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libin","family":"Wen","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture National Center for Engineering Research of Veterinary Bio\u2010products Nanjing 210000 China"},{"name":"Jiangsu Co\u2010innovation Center for 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