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It was recently reported by our team that T cells from SATB1 conditional knockout (SATB1cKO) mice, in which the <jats:italic>Satb1<\/jats:italic> gene is deleted from hematopoietic cells, impair phosphorylation of signaling molecules in response to T cell receptor (TCR) crosslinking. However, <jats:italic>in vivo<\/jats:italic> T cell responses upon antigen presentation in the absence of SATB1 remain unclear. In the current study, it was shown that SATB1 modulates T cell antigen responses during the induction and effector phases. Expression of SATB1 was upregulated in response to TCR stimulation, suggesting that SATB1 is important for this antigen response. The role of SATB1 in TCR responses and induced experimental autoimmune encephalomyelitis (EAE) was therefore examined using the myelin oligodendrocyte glycoprotein peptide 35\u201055 (MOG35\u201055) and pertussis toxin. SATB1cKO mice were found to be resistant to EAE and had defects in IL\u201017\u2010 and IFN\u2010\u03b3\u2010producing pathogenic T cells. Thus, SATB1 expression appears necessary for T cell function in the induction phase. To examine SATB1 function during the effector phase, a tamoxifen\u2010inducible SATB1 deletion system, SATB1cKO\u2010ER\u2010Cre mice, was used. Encephalitogenic T cells from MOG35\u201055\u2010immunized SATB1cKO\u2010ER\u2010Cre mice were transferred into healthy mice. Mice that received tamoxifen before the onset of paralysis were resistant to EAE. Furthermore, no disease progression occurred in recipient mice treated with tamoxifen after the onset of EAE. Thus, SATB1 is essential for maintaining TCR responsiveness during the induction and effector phases and may provide a novel therapeutic target for T cell\u2010mediated autoimmune diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12579","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T12:42:34Z","timestamp":1517488954000},"page":"255-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Special AT\u2010rich sequence binding protein 1 is required for maintenance of T cell receptor responsiveness and development of experimental autoimmune encephalomyelitis"],"prefix":"10.1111","volume":"62","author":[{"given":"Yasushi","family":"Akiba","sequence":"first","affiliation":[{"name":"Department of Molecular Immunology Toho University School of Medicine Tokyo 143\u20108540 Japan"},{"name":"Toho University Graduate School of Medicine Tokyo 143\u20108540 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