{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:37:08Z","timestamp":1780097828127,"version":"3.54.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>We aimed to assess the immunoregulatory effects of IFN\u2010\u03b2 in patients with tuberculous pleurisy. IFN\u2010\u03b2, IFN\u2010\u03b3 and IL\u201017 expression levels were detected, and correlations among these factors in different culture groups were analyzed. Pleural fluid mononuclear cells (PFMC) from tuberculous pleural effusions, but not peripheral blood mononuclear cells (PBMC) from healthy donors, spontaneously expressed IFN\u2010\u03b2, IL\u201017 and IFN\u2010\u03b3. Moreover, exogenous IFN\u2010\u03b2 significantly inhibited the expression of IL\u201017 in PFMC. By contrast, IFN\u2010\u03b2 simultaneously enhanced the levels of IFN\u2010\u03b3. To further investigate the regulation of IL\u201017 and IFN\u2010\u03b3 by endogenous IFN\u2010\u03b2, an IFN\u2010\u03b2 neutralizing antibody was simultaneously added to bacillus Calmette\u2010Gu\u00e9rin (BCG)\u2010stimulated PFMC. IL\u201017 expression was significantly increased, but IFN\u2010\u03b3 production was markedly decreased in the experimental group supplemented with the IFN\u2010\u03b2 neutralizing antibody. Simultaneously, IL\u201017 production was remarkably increased in the experimental group supplemented with the IFN\u2010\u03b3 neutralizing antibody. Taken together, in our study, we first found that freshly isolated PFMC, but not PBMC from healthy donors, spontaneously expressed IFN\u2010\u03b2, IL\u201017 and IFN\u2010\u03b3 <jats:italic>in vivo<\/jats:italic>. Moreover, IFN\u2010\u03b2 suppressed IL\u201017 expression and increased IFN\u2010\u03b3 production. Furthermore, both IFN\u2010\u03b2 and IFN\u2010\u03b3 down\u2010regulated IL\u201017 expression. These observations suggest that caution is required when basing anti\u2010tuberculosis treatment on the inhibition of IFN\u2010\u03b2 signaling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12583","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T08:12:38Z","timestamp":1520237558000},"page":"281-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The immune characterization of interferon\u2010\u03b2 responses in tuberculosis patients"],"prefix":"10.1111","volume":"62","author":[{"given":"Xiao","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Department of Molecular Diagnostics Sun Yat\u2010Sen University Cancer Center Collaborative Innovation Center for Cancer Medicine Guangzhou 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