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In the present work, the mechanisms for the anti\u2010HCMV effects of tricin in HEL cells were examined. It was found that exposure of HEL cells to tricin inhibited HCMV replication, with concomitant decreases in amounts of transcripts of the CC chemokine RANTES (CCL5)\u2010encoding gene and in expression of the CCL5 protein. It was also found that transcripts of HCMV immediate early 1 (<jats:italic>IE1<\/jats:italic>), and HCMV <jats:italic>UL54<\/jats:italic> (encoding DNA polymerase) and replication of HCMV was significantly lower in <jats:italic>CCL5<\/jats:italic> gene\u2010knockdown cells. These results suggest that the anti\u2010HCMV activity of tricin differs from that of ganciclovir and that CCL5 is one of the chemokines involved in HCMV replication. In addition, it is possible that chemokine CCL5 is one of the targets of tricin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12590","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T01:14:54Z","timestamp":1522458894000},"page":"341-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tricin inhibits the CCL5 induction required for efficient growth of human cytomegalovirus"],"prefix":"10.1111","volume":"62","author":[{"given":"Akimasa","family":"Itoh","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Pharmaceutical Sciences Hokuriku University Ho\u20103 Kanagawa\u2010machi Kanazawa 920\u20101181 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Sadanari","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Pharmaceutical Sciences Hokuriku 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