{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:08:00Z","timestamp":1790791680537,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p><jats:italic>Capnocytophaga canimorsus<\/jats:italic> and <jats:italic>Capnocytophaga cynodegmi<\/jats:italic>, both commensal bacteria in the oral cavities of dogs and cats, are zoonotic pathogens. In particular, <jats:italic>C. canimorsus<\/jats:italic> causes sepsis and fatal septic shock. Recently, a novel <jats:italic>Capnocytophaga<\/jats:italic> species, <jats:italic>C. canis<\/jats:italic>, was isolated from the oral cavities of healthy dogs. It is reportedly oxidase\u2010negative and therefore considered avirulent in humans. In the present study, three strains of <jats:italic>C. canis<\/jats:italic> were isolated from Japanese patients with sepsis. All three strains, HP20001, HP33001 and HP40001, were oxidase\u2010positive. Nucleotide sequence identities of the 16S rRNA gene of the three strains to the <jats:italic>C. canimorsus<\/jats:italic> type strain ATCC35979, <jats:italic>C. cynodegmi<\/jats:italic> type strain ATCC49044 and <jats:italic>C. canis<\/jats:italic> type strain LMG29146 were 96.9\u201397.0%, 96.9\u201397.0% and 99.7\u201399.8%, respectively. Multi\u2010locus sequence analysis based on seven house\u2010keeping genes, <jats:italic>dnaJ<\/jats:italic>, <jats:italic>fumC, glyA<\/jats:italic>, <jats:italic>gyrB<\/jats:italic>, <jats:italic>murG<\/jats:italic>, <jats:italic>trpB<\/jats:italic> and <jats:italic>tuf<\/jats:italic>, revealed that the oxidase\u2010positive <jats:italic>C. canis<\/jats:italic> strains isolated in Japan and oxidase\u2010negative strains of <jats:italic>C. canis<\/jats:italic> from canine oral cavities in Switzerland were clustered in different genetic subgroups. These results indicate that the virulence of <jats:italic>C. canis<\/jats:italic> strains in humans is associated with oxidase activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12642","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T12:35:03Z","timestamp":1534509303000},"page":"567-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Characterization of three strains of <i>Capnocytophaga canis<\/i> isolated from patients with sepsis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-6251","authenticated-orcid":false,"given":"Michio","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Veterinary Science National Institute of Infectious Diseases 1\u201023\u20101 Toyama Shinjuku\u2010ku, Tokyo 162\u20108640 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Imaoka","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science National Institute of Infectious Diseases 1\u201023\u20101 Toyama Shinjuku\u2010ku, Tokyo 162\u20108640 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Haga","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Japan Community Healthcare Organization Kyushu Hospital 1\u20108\u20101 Kishinoura Yahatanishi\u2010ku, Kitakyushu Fukuoka 806\u20108501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Mohri","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japan Community Healthcare Organization Kyushu Hospital 1\u20108\u20101 Kishinoura Yahatanishi\u2010ku, Kitakyushu Fukuoka 806\u20108501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Nogami","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Iida Municipal Hospital 438 Yawatacho, Iida Nagano 395\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Shimojima","sequence":"additional","affiliation":[{"name":"Department of Neurology Iida Municipal Hospital 438 Yawatacho, Iida Nagano 395\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Irie","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Okayama Kyoritsu General Hospital 8\u201010 Akasaka\u2010honmachi Naka\u2010ku, Okayama 703\u20108511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Sugimura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Okayama Kyoritsu General Hospital 8\u201010 Akasaka\u2010honmachi Naka\u2010ku, Okayama 703\u20108511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science National Institute of Infectious Diseases 1\u201023\u20101 Toyama Shinjuku\u2010ku, Tokyo 162\u20108640 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00408040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.2.231-235.1989"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-44-2-324"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.65373-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2015.48"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.5.1045"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.01.040"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22919"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2360-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/510243"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38914"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1606-x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102012\u2010007892"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9196-17"},{"key":"e_1_2_7_16_1","first-page":"S1 290","article-title":"A case of septicemia caused by putative novel species of genus Capnocytophaga","volume":"25","author":"Irie Y.","year":"2015","journal-title":"J Jpn Soc Clin Microbiol"},{"key":"e_1_2_7_17_1","unstructured":"National Center for Biotechnology Information.Resources. 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