{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:02:31Z","timestamp":1790067751875,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Leukocyte immunoglobulin like receptor B1 (LILRB1) plays a significant role in a number of infectious, autoimmune, cardiovascular, and oncologic disorders. LILRB1 expression varies between individuals and may be associated with polymorphisms on the regulatory region of the <jats:italic>LILRB1<\/jats:italic> gene, as well as to previous cytomegalovirus infection. In this study, the contribution of these two factors to LILRB1 expression in peripheral blood mononuclear cells of healthy young adults was analyzed. LILRB1 expression in NK cells, T cells, B cells and monocytes was significantly stronger in individuals who had had cytomegalovirus infection than in those who had not (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively). Overall, no differences in LILRB1 expression were observed between individuals with and without GAA haplotypes of the <jats:italic>LILRB1<\/jats:italic> regulatory region. However, when analyzed according to cytomegalovirus infection status, significant differences in LILRB1+ NK cells were observed. A higher proportion of LILRB1+ cells was found in GAA+ than in GAA\u2212 individuals who had not been infected (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), whereas GAA\u2212 individuals had a larger proportion of LILRB1+ cells than GAA+ individuals who were cytomegalovirus positive (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). In conclusion, cytomegalovirus infection has a major effect on LILRB1 expression in NK and other mononuclear cells and polymorphisms in the <jats:italic>LILRB1<\/jats:italic> regulatory region appear to have a modulatory influence over this effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12661","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T11:01:11Z","timestamp":1542798071000},"page":"755-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of cytomegalovirus infection and leukocyte immunoglobulin like receptor B1 polymorphisms on receptor expression in peripheral blood mononuclear cells"],"prefix":"10.1111","volume":"62","author":[{"given":"Sandra","family":"Cadena\u2010Mota","sequence":"first","affiliation":[{"name":"Faculty of Medicine Microbiology Department Autonomous University of San Luis Potos\u00ed 2405 Venustiano Carranza Avenue, Colonia los 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