{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:03:58Z","timestamp":1777539838184,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["AMED JP18fk0108013"],"award-info":[{"award-number":["AMED JP18fk0108013"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>A total of 300 patients with nucleic acid test\u2010confirmed rubella, mostly adults, were investigated to determine the clinical value of a rubella\u2010specific IgM test using an EIA kit. IgM titers increased after rash onset, the median IgM titer being significantly higher 3 days post\u2010onset than on previous days (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Similarly, the IgM\u2010positive rate at 3 days post\u2010onset (61.5%) was significantly higher than on previous days (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). This IgM test against rubella at 3 days or more post\u2010disease onset provides the clinically relevant information.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1348-0421.12664","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T10:17:52Z","timestamp":1544782672000},"page":"32-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical value of enzyme immunoassay that detects rubella\u2010specific immunoglobulin M immediately after disease onset"],"prefix":"10.1111","volume":"63","author":[{"given":"Takako","family":"Kurata","sequence":"first","affiliation":[{"name":"Osaka Institute of Public Health 1\u20103\u201069, Nakamichi Higashinari\u2010ku Osaka 537\u20100025 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoko","family":"Uchino","sequence":"additional","affiliation":[{"name":"Sakai City Institute of Public health 3\u20102\u20108, Kaicho\u2010higashi, Sakai\u2010ku Sakai\u2010City Osaka 590\u20100953 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiemi","family":"Hotta","sequence":"additional","affiliation":[{"name":"Chiba Prefectural Institute of Public Health 666\u20102, Nitona\u2010cho, Chuo\u2010 ku Chiba\u2010City Chiba 260\u20108715 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Kimitsu Health Center 3\u20104\u201034, Shinden Kisarazu\u2010City Chiba 292\u20100832 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Sakai City Institute of Public health 3\u20102\u20108, Kaicho\u2010higashi, Sakai\u2010ku Sakai\u2010City Osaka 590\u20100953 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Chiba Prefectural Institute of Public Health 666\u20102, Nitona\u2010cho, Chuo\u2010 ku Chiba\u2010City Chiba 260\u20108715 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Kanbayashi","sequence":"additional","affiliation":[{"name":"Osaka Institute of Public Health 1\u20103\u201069, Nakamichi Higashinari\u2010ku Osaka 537\u20100025 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Sakai City Institute of Public health 3\u20102\u20108, Kaicho\u2010higashi, Sakai\u2010ku Sakai\u2010City Osaka 590\u20100953 Japan"},{"name":"Hidaka General Hospital 116\u20102, Sono Gobo\u2010City Wakayama 644\u20100002 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yumisashi","sequence":"additional","affiliation":[{"name":"Osaka Institute of Public Health 1\u20103\u201069, Nakamichi Higashinari\u2010ku Osaka 537\u20100025 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Komano","sequence":"additional","affiliation":[{"name":"National Hospital Organization Nagoya Medical Center 4\u20101\u20101, Sannomaru, Naka\u2010ku Nagoya\u2010City Aichi 460\u20100001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"325","volume-title":"Epidemiology and Prevention of Vaccine\u2010Preventable Diseases","author":"Hamborsky J","year":"2015"},{"key":"e_1_2_5_3_1","unstructured":"World Health Organization. Manual for the Laboratory\u2010based Surveillance of Measles Rubella and Congenital Rubella Syndrome. 3rd ed. 2017 (version January 2018) Available at:http:\/\/www.who.int\/immunization\/monitoring_surveillance\/burden\/laboratory\/manual\/en\/"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01231-08"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(91)90119-K"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.05.005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01513"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/applin\/amv025"},{"key":"e_1_2_5_9_1","first-page":"73","article-title":"Nested reverse transcription polymerase chain reaction for the detection of rubella virus in clinical specimens","volume":"125","author":"Shyamala G","year":"2007","journal-title":"Indian J Med Res"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00289-07"},{"key":"e_1_2_5_11_1","first-page":"233","volume":"30","author":"Tipples GA","year":"2004","journal-title":"atnam S. 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