{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:35:40Z","timestamp":1768516540406,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18fk0108005"],"award-info":[{"award-number":["JP18fk0108005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One\u2010third of the world's humans has latent tuberculosis infection (LTBI), representing a large pool of potentially active TB. Recent LTBI carries a higher risk of disease progression than remote LTBI. Recent studies suggest important roles of antibodies in TB pathology, prompting us to investigate serum antibody profiles in a cohort with LTBI. In this single\u2010center prospective observational study, we analyzed IgG\u2010antibody concentrations against five major <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (<jats:italic>Mtb<\/jats:italic>) antigens (including 6 kDa early secretory antigenic target (ESAT6), CFP10, and antigen 85A, which are expressed mainly in the growth phase; and mycobacterial DNA\u2010binding protein 1 (MDP1) and alpha\u2010crystallin like protein (Acr), which are expressed in the dormant phases) in individuals with recent (<jats:italic>n<\/jats:italic>=13) or remote (<jats:italic>n<\/jats:italic>=12) LTBI, no <jats:italic>Mtb<\/jats:italic> infection (<jats:italic>n<\/jats:italic>=19), or active TB (<jats:italic>n<\/jats:italic>=15). Antibody titers against ESAT6 and MDP1 were significantly higher in individuals with recent LTBI than in those with no <jats:italic>Mtb<\/jats:italic> infection or remote LTBI. All pairwise antibody titers against these five major antigens were significantly correlated throughout the stages of <jats:italic>Mtb<\/jats:italic> infection. Five individuals with recent LTBI had significantly higher antibody titers against ESAT6 (<jats:italic>P<\/jats:italic> = 0.03), Ag85A (<jats:italic>P<\/jats:italic> = 0.048), Acr (<jats:italic>P<\/jats:italic> = 0.057), and MDP1 (<jats:italic>P<\/jats:italic> = 0.0001) than in individuals with remote LTBI; they were also outside the normal range (+2 SDs). One of these individuals was diagnosed with active pulmonary TB at 18\u2010month follow\u2010up examination. These findings indicated that concentrations of antibodies against both multiplying and dormant <jats:italic>Mtb<\/jats:italic> are higher in recent LTBI and that individuals with markedly higher antibody titers may be appropriate candidates for prophylactic therapy.<\/jats:p>","DOI":"10.1111\/1348-0421.12674","type":"journal-article","created":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T13:49:04Z","timestamp":1552139344000},"page":"130-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Serum antibody profiles in individuals with latent <i>Mycobacterium tuberculosis<\/i> infection"],"prefix":"10.1111","volume":"63","author":[{"given":"Ryoji","family":"Maekura","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Toneyama National Hospital Toyonaka Osaka Japan"},{"name":"Graduate School of Health Care Sciences, Jikei Institute  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seigo","family":"Kitada","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Toneyama National Hospital Toyonaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Osada\u2010Oka","sequence":"additional","affiliation":[{"name":"Food Hygiene and Environmental Health, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Bacteriology Niigata University Graduate School of Medicine Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Ozeki","sequence":"additional","affiliation":[{"name":"Department of Bacteriology Niigata University Graduate School of Medicine Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeya","family":"Fujicawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Toneyama National Hospital Toyonaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Toneyama National Hospital Toyonaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ogawa","family":"Jyunnko","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Toneyama National Hospital Toyonaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Toneyama National Hospital Toyonaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohkichi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Bacteriology Niigata University Graduate School of Medicine Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"key":"e_1_2_8_1_2_1","volume-title":"Global Tuberculosis Report 2016","author":"World Health Organization","year":"2016"},{"key":"e_1_2_8_1_3_1","first-page":"1376","article-title":"Diagnostic standards and classification of tuberculosis in adults and children. This official statement of the American Thoracic Society and the Centers for Disease Control and Prevention was adopted by the ATS Board of Directors, July 1999. 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