{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:09:56Z","timestamp":1769101796658,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IL\u201017is one of the most important inflammatory cytokines that stimulate immunity responses in humans infected with <jats:italic>Brucella<\/jats:italic> species, acting as a regulator that reduces release of \u03b3\u2010IFN, thus increasing resistance to brucellosis. Gene polymorphisms in the regulatory regions of cytokine\u2010encoding genes affect the amountsof cytokines produced and play a fundamental role in infectious diseases. The aim of this study was to determine the association between IL\u201017 gene polymorphisms and susceptibility to brucellosis. In this case\u2010control study, 86 patients with brucellosis and 86 healthy persons in Hamadan, western Iran, from September 2014 to September 2016, were included. IL\u201017 genetic variants at positions rs4711998 A\/G, rs8193036 C\/T, rs3819024 A\/G, rs2275913 A\/G, rs3819025 A\/G, rs8193038 A\/G, rs3804513 A\/T, rs1974226 A\/G and rs3748067 A\/G were analyzed by restriction fragment length polymorphism\u2010PCR. Serum IL\u201017 titers were measured by sandwich ELISA. GG genotypes at positions rs4711998 and rs3748067 were present significantly more frequently in patients with brucellosis than in controls (<jats:italic>P<\/jats:italic> &lt; 0.05). The AA genotype at positions rs4711998, rs2275913 and rs3748067 and GG genotype at position rs19744226 were present significantly more frequently in controls than in the patient group. These results suggest that the AA genotype at positions rs3748067, rs3819025 and rs4711998 and GG genotype at position rs3819024 are likely protective factors against brucellosis, whereas the GG genotype at positions rs3748067, rs3819025 and rs4711998 and AA genotype at position rs3819024 may be risk factors against the disease. No significant relationships were found between serum IL\u201017 titers and genotypes of the single\u2010nucleotide polymorphisms.<\/jats:p>","DOI":"10.1111\/1348-0421.12675","type":"journal-article","created":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T13:50:19Z","timestamp":1552139419000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of interleukin\u201017 gene polymorphisms and susceptibility to brucellosis in Hamadan, western Iran"],"prefix":"10.1111","volume":"63","author":[{"given":"Fariba","family":"Keramat","sequence":"first","affiliation":[{"name":"Brucellosis Research Center Hamadan University of Medical Sciences Hamadan Iran"},{"name":"Department of Infectious Diseases Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sima","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Department 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