{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:58:43Z","timestamp":1789966723622,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gut microbes symbiotically colonize the gastrointestinal (GI) tract, interacting with each other and their host to maintain GI tract homeostasis. Recent reports have shown that gut microbes help protect the gut from colonization by pathogenic microbes. Here, we report that commensal microbes prevent colonization of the GI tract by the pathogenic fungus, <jats:italic>Candida albicans<\/jats:italic>. Wild\u2010type specific pathogen\u2010free (SPF) mice are resistant to <jats:italic>C. albicans<\/jats:italic> colonization of the GI tract. However, administering certain antibiotics to SPF mice enables <jats:italic>C. albicans<\/jats:italic> colonization. Quantitative kinetics of commensal bacteria are inversely correlated with the number of <jats:italic>C. albicans<\/jats:italic> in the gut. Here, we provide further evidence that transplantation of fecal microbiota is effective in preventing <jats:italic>Candida<\/jats:italic> colonization of the GI tract. These data demonstrate the importance of commensal bacteria as a barrier for the GI tract surface and highlight the potential clinical applications of commensal bacteria in preventing pathogenic fungal infections.<\/jats:p>","DOI":"10.1111\/1348-0421.12680","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T08:40:27Z","timestamp":1553762427000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Fecal microbiota transplantation prevents <i>Candida albicans<\/i> from colonizing the gastrointestinal tract"],"prefix":"10.1111","volume":"63","author":[{"given":"Kenzo","family":"Matsuo","sequence":"first","affiliation":[{"name":"Division of Molecular Immunology Medical Mycology Research Center, Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Haku","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology Medical Mycology Research Center, Chiba University Chiba Japan"},{"name":"Division of Innate Immunity, Department of Microbiology and Immunology Institute of Medical Science, The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Bi","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology Medical Mycology Research Center, Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Bio\u2010resources Medical Mycology Research Center, Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Kamada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yaguchi","sequence":"additional","affiliation":[{"name":"Division of Bio\u2010resources Medical Mycology Research Center, Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Saijo","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology Medical Mycology Research Center, Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutoshi","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology Medical Mycology Research Center, Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-5583","authenticated-orcid":false,"given":"Yoshiyuki","family":"Goto","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology Medical Mycology Research Center, Chiba University Chiba Japan"},{"name":"Division of Mucosal Symbiosis International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4517"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3780"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3535"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170495"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.04.002"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.004"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222195"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205037"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00238"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1221789"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1315399"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-36-6-428"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.49.3.654-663.1985"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7999"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08131"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.002"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240537"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254009"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07450"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-31"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.12.010"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.003"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.033"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.001"},{"key":"e_1_2_8_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.09.009"},{"key":"e_1_2_8_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.13324"},{"key":"e_1_2_8_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.07.003"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.12680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1348-0421.12680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.12680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T16:28:09Z","timestamp":1694363289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1348-0421.12680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/1348-0421.12680"],"URL":"https:\/\/doi.org\/10.1111\/1348-0421.12680","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"value":"0385-5600","type":"print"},{"value":"1348-0421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"2018-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}