{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:57:08Z","timestamp":1740149828870,"version":"3.37.3"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 2018, a patient was diagnosed with Shimokoshi type scrub typhus in Yamagata Prefecture, Japan. The causative pathogen was likely a variant type because 43 (8.3%) of 521 deduced amino acid sequences of the 56\u2010kDa type\u2010specific antigen (TSA) were different from those of the Shimokoshi prototype strain. The patient's paired sera showed low antibody titers against the Shimokoshi prototype strain. Two cases of scrub typhus reported in the Tohoku region during 2011\u20132012 also involved the same 56\u2010kDa TSA gene sequence. These findings suggest the presence of diversity in Shimokoshi type <jats:italic>Orientia tsutsugamushi<\/jats:italic>, which may impede the laboratory diagnosis of scrub typhus.<\/jats:p>","DOI":"10.1111\/1348-0421.12690","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T12:46:51Z","timestamp":1557838011000},"page":"280-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Scrub typhus caused by Shimokoshi type <i>Orientia tsutsugamushi<\/i> showing variant 56\u2010kDa type\u2010specific antigen gene sequence in Tohoku region, Japan"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2227-5315","authenticated-orcid":false,"given":"Junji","family":"Seto","sequence":"first","affiliation":[{"name":"Department of Microbiology Yamagata Prefectural Institute of Public Health Yamagata City Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Microbiology Yamagata Prefectural Institute of Public Health Yamagata City Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Murakata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asahi Town Hospital Asahi Town Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Health and Hygiene Akita Prefectural Research Center for Public Health and Environment Akita City Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naota","family":"Monma","sequence":"additional","affiliation":[{"name":"Department of Microbiology Fukushima Prefectural Institute of Public Health Fukushima City Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Arai","sequence":"additional","affiliation":[{"name":"Division of Virology Niigata Prefectural Institute of Public Health and Environmental Sciences Niigata City Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Microbiology Yamagata Prefectural Institute of Public Health Yamagata City Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Department of Microbiology Yamagata Prefectural Institute of Public Health Yamagata City Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"e_1_2_4_1_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/596576"},{"key":"e_1_2_4_1_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed3010008"},{"key":"e_1_2_4_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1984.tb00743.x"},{"key":"e_1_2_4_1_5_1","doi-asserted-by":"publisher","DOI":"10.7601\/mez.60.317"},{"key":"e_1_2_4_1_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.12-0740"},{"key":"e_1_2_4_1_7_1","doi-asserted-by":"publisher","DOI":"10.7601\/mez.65.183"},{"key":"e_1_2_4_1_8_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2017.447"},{"key":"e_1_2_4_1_9_1","doi-asserted-by":"crossref","first-page":"12728","DOI":"10.1016\/S0021-9258(18)42337-X","article-title":"Diversity of immunodominant 56\u2010kDa type\u2010specific antigen (TSA) of Rickettsia tsutsugamushi. 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