{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:31:51Z","timestamp":1790076711554,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>mTOR inhibitors exert a preventive effect on cytomegalovirus (CMV) disease in CMV seropositive (R+) kidney transplant recipients, but their impact during the curative treatment of CMV disease in high\u2010risk kidney transplant recipients has not been investigated. We aimed to evaluate the efficacy and tolerance of mTOR inhibitors compared with mycophenolic acid in 63 consecutive kidney transplant recipients (80% of D+R\u2212) suffering from CMV disease with a persistent or a recurrent CMV DNAemia. In this monocentric retrospective study, 16 had their treatment converted to mTOR inhibitors and 47 did not. The Kaplan\u2013Meier curves did not show any significant differences in CMV DNAemia eradication (77% vs. 88% respectively; hazard ratio (HR), 1.648 [95% confidence interval (CI), 0.913\u20132.973]; log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009=\u2009.132), DNAemia recurrence (36% vs. 47%; HR, 1.517 [95% CI, 0.574\u20134.007]; log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009=\u2009.448) and CMV clinical recurrence (17% vs. 27%; HR, 1.375 [95% CI, 0.340\u20135.552]; log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009=\u2009.677) between patients who received mTOR inhibitors and those who did not. These results were confirmed in uni\u2010 and multivariate time\u2010dependent Cox regressions. In summary, conversion from mycophenolic acid to mTOR inhibitors seems inadequate for improving CMV clearance or in better preventing CMV recurrences during severe or persistent CMV disease.<\/jats:p>","DOI":"10.1111\/1348-0421.12794","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T10:41:41Z","timestamp":1586169701000},"page":"520-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of mTOR inhibitors during CMV disease in kidney transplant recipients: Results of a pilot retrospective study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-3825","authenticated-orcid":false,"given":"Hannah","family":"Kaminski","sequence":"first","affiliation":[{"name":"Department of Nephrology, Transplantation, Dialysis and Apheresis Pellegrin University Hospital  Bordeaux France"},{"name":"CNRS\u2010UMR 5164 ImmunoConcEpT Bordeaux University  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