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A decrease of thymic epithelial cells is the main cause of age\u2010related thymic atrophy or degeneration. Resveratrol (RSV), a phytoalexin produced from plants, has been shown to inhibit the adverse effects of dietary obesity on the structure and function of the thymus. D\u2010Galactose (D\u2010gal) can induce accelerated aging in mice. In the present study, young mice (2 months old) were injected with D\u2010gal (120\u2009mg\/kg\/day) for 8 consecutive weeks to construct an accelerated aging model. Compared with normal control mice, the thymus epithelium of the D\u2010gal treated mice had structural changes, the number of senescent cells increased, the number of CD4+ T cells decreased, and CD8+ T cells increased. After RSV administration by gavage for 6 weeks, it was found that RSV improved the surface phenotypes of D\u2010gal treated mice, and recovered thymus function by maintaining the ratio of CD4+ to CD8+ cells. It also indicated that RSV enhanced the cell proliferation and inhibited cell senescence. Increased autoimmune regulator (Aire) expression was present in the RSV treated mice. The lymphotoxin\u2010beta receptor (LT\u03b2R) expression also increased. These findings suggested that RSV intake could restore the alterations caused by D\u2010gal treatment in the thymus via stimulation of Aire expression.<\/jats:p>","DOI":"10.1111\/1348-0421.12833","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T11:04:40Z","timestamp":1595329480000},"page":"620-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Resveratrol ameliorates thymus senescence changes in D\u2010galactose induced mice"],"prefix":"10.1111","volume":"64","author":[{"given":"Ting\u2010ting","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medical Sciences Zhengzhou University  Zhengzhou Henan Province China"},{"name":"Population and Family Planning Science and Technology Research Institute of Henan  Zhengzhou Henan Province 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