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In the present study examined the differences in the mechanisms involved in virus\u2010induced cell death and innate immune responses between the DTMUV KPS54A61 strain and the JEV JaGAr\u201001 strain using primary duck neurons (DN) and duck fibroblasts (CCL\u2010141). DN and CCL\u2010141 were permissive for the infection and replication of these two viruses, which up\u2010regulated the expression of innate immunity genes. Both DTMUV and JEV induced cell death via a caspase\u20103\u2010dependent manner; however, DTMUV triggered more cell death than did JEV in both CCL\u2010141 and DN. These findings suggest that DTMUV infection causes apoptosis in duck neurons and fibroblasts more strongly than JEV. The levels of the mRNA expression of innate immunity\u2010related genes after DTMUV infection were generally higher than the levels after JEV infection, suggesting that DTMUV\u2010induced immune response in duck cells may exhibit toxic effects rather than protective effects.<\/jats:p>","DOI":"10.1111\/1348-0421.12933","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T13:03:17Z","timestamp":1626267797000},"page":"481-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Duck Tembusu virus induces stronger cellular responses than Japanese encephalitis virus in primary duck neurons and fibroblasts"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5799-2659","authenticated-orcid":false,"given":"Sittinee","family":"Kulprasertsri","sequence":"first","affiliation":[{"name":"Laboratory of Comparative Pathology, Department of Clinical Sciences, Faculty 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