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In this case\u2013control study, which included 81 human T\u2010cell leukemia virus type 1 (HTLV\u20101) asymptomatic carriers (AC) and 162 healthy controls (HC), the rs4143815 polymorphism of PDL1 gene was investigated. This polymorphism is the site of miR\u2010570 binding and it can influence immune system responses. The rs4143815 polymorphism was evaluated by allele\u2010specific polymerase chain reaction (AS\u2010PCR) and the proviral load levels by quantitative real\u2010time PCR (q PCR). The results demonstrated that the C allele (<jats:italic>P<\/jats:italic>\u2009=\u20090.027) and the CC genotype (<jats:italic>P<\/jats:italic>\u2009=\u20090.031) of rs4143815 polymorphism was significantly higher in the AC group than in the HC group, also the proviral load in the AC group with the C allele (<jats:italic>P<\/jats:italic>\u2009=\u20090.020) was significantly higher. Thus, the rs4143815 polymorphism can play a vital role in HTLV\u20101 infection<\/jats:p>","DOI":"10.1111\/1348-0421.12976","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T09:26:27Z","timestamp":1647336387000},"page":"324-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of the rs4143815 polymorphism of PDL1 gene with HTLV\u20101 infection and proviral load in asymptomatic blood donors in northeast Iran"],"prefix":"10.1111","volume":"66","author":[{"given":"Yalda Amiri","family":"Hezave","sequence":"first","affiliation":[{"name":"Blood Transfusion Research Center High Institute for Research and Education in Transfusion Medicine Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6600-910X","authenticated-orcid":false,"given":"Zohreh","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Blood 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