{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T16:29:02Z","timestamp":1744734542194,"version":"3.37.3"},"reference-count":114,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K09530\/21H03386"],"award-info":[{"award-number":["21K09530\/21H03386"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevention of the disease severity seems critical for reducing the mortality of Coronavirus (CoV) disease\u201019. The neutrophils play a key role in the induction of severity. It is proposed here that inhibition of neutrophil activation and\/or cascade reactions of complement, leading to this cell activation at the early phase of the disease, is a potential tool to inhibit aggravation of the disease. The need for appropriate timing in intervention is emphasized as follows. (1) Intervention at the very early stage of severe acute respiratory syndrome\u2010CoV\u20102 infection may harm the defensive host response to the infection because of the critical function of neutrophils in this response, and (2) intervention at too late a stage will not stop the infiltration of fully activated neutrophils that produce large amounts of toxic substances.<\/jats:p>","DOI":"10.1111\/1348-0421.12978","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T10:04:48Z","timestamp":1648548288000},"page":"264-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting of neutrophil activation in the early phase of the disease for prevention of Coronavirus disease\u201019 severity"],"prefix":"10.1111","volume":"66","author":[{"given":"Fujiro","family":"Sendo","sequence":"first","affiliation":[{"name":"Department of Immunology (Professor Emeritus) Yamagata University School of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yoshitake","sequence":"additional","affiliation":[{"name":"Institute for Environmental and Gender\u2010specific Medicine Juntendo University Graduate School of Medicine Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-9765","authenticated-orcid":false,"given":"Yoshihiko","family":"Araki","sequence":"additional","affiliation":[{"name":"Institute for Environmental and Gender\u2010specific Medicine Juntendo University Graduate School of Medicine Urayasu Chiba Japan"},{"name":"Division of Microbiology, Department of Pathology and Microbiology Nihon University School of Medicine Itabashi Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32661-1"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01410-w"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2105000"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101143"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00460-6"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03944-y"},{"key":"e_1_2_13_9_1","unstructured":"WHO Newsletter. Classification of Omicron (B.1.1.529): SARS\u2010CoV\u20102 Variant of Concern.20212[cited 2021 November 6]. Available from:https:\/\/www.who.int\/news\/item\/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.03.021"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.037"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2588-y"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1633"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12671"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.652470"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1443.020"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17665-9"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00575-7"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.59943"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00619-y"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01257-21"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.580"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72718-9"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abd6197"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0901-9"},{"key":"e_1_2_13_27_1","first-page":"99","article-title":"Virus\u2010host interactome and proteomic survey reveal potential virulence factors influencing SARS\u2010CoV\u20102 pathogenesis","volume":"2","author":"Li J","year":"2021","journal-title":"Med (N Y)"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24360-w"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6261"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1051-9"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00840-x"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04421-w"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.24"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2026131"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8925"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.017"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13144"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000822"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41763"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.6820"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.11330"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.9508"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00553-8"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01500-9"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02897-4"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01499-z"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.001"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.04.002"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02374-0"},{"key":"e_1_2_13_53_1","article-title":"Lymphopenia and neutrophilia at admission predicts severity and mortality in patients with COVID\u201019: a meta\u2010analysis","volume":"91","author":"Henry B","year":"2020","journal-title":"Acta Biomed"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79431-7"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.91868"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0944-y"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14333"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc14003"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.018"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-0168-9"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0069-0"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2020.04.007"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00138"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00311.2013"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.48.3.258"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.9.2902"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A1213-628R"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.02.010"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2600-6"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-00357-4"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02886-6"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8829674"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200652"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061383"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-021-00805-z"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-768507"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00823-5"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.005"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0736-z"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2009.224"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00550"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201012"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007008"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12967"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1209793"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00217"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-9925-z"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-019-0381-5"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1155\/1994\/74202"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201509-1818OC"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-009-9152-0"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.1.58"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.01.022"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.7.4277"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.5.763"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.71.2.205"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.5.650"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704860"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2001.tb02646.x"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.8.4157"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.69.1.57"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.54.299"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0054-z"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2014.922876"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.08.016"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201405-0992OC"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.12.009"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.03.056"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051113-024537"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507247"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01643-9"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201342"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6182"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14746"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003568"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.12978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1348-0421.12978","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.12978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:01:33Z","timestamp":1692874893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1348-0421.12978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":114,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/1348-0421.12978"],"URL":"https:\/\/doi.org\/10.1111\/1348-0421.12978","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"type":"print","value":"0385-5600"},{"type":"electronic","value":"1348-0421"}],"subject":[],"published":{"date-parts":[[2022,4,20]]},"assertion":[{"value":"2022-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}