{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:12:36Z","timestamp":1780542756892,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91742101"],"award-info":[{"award-number":["91742101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["160808MH160"],"award-info":[{"award-number":["160808MH160"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A well preserved immune system is a powerful tool to prevent foreign invasion or to suppress internal mutation, which must be tightly controlled by co\u2010stimulatory molecules in different pathophysiological conditions. One such critical molecule is OX40L expressed on activated antigen\u2010presenting cells (APCs). Consistently, its abnormality is associated with various immunological disorders such as autoinflammatory diseases and allergy. However, a comprehensive analysis of the immune\u2010moderating role of OX40L in dendritic cells (DCs), the most powerful APCs to initiate immune responses in vivo, and investigation of its anti\u2010tumor efficacy in the disease setting have not been performed properly. In this study, genetic approaches for both gain\u2010of\u2010function and reduction\u2010of\u2010function were employed to reveal that OX40L was required for the efficient presentation, but not uptake, of antigens by DCs to stimulate CD4<jats:sup>+<\/jats:sup>, as well as CD8<jats:sup>+<\/jats:sup> T cells in vivo. As a result, CD4<jats:sup>+<\/jats:sup> T cells were promoted towards Th1, but inhibited on Treg differentiation, by the LPS\u2010induced OX40L on DCs, which was supported by their altered expression of co\u2010inhibitory receptor, PD\u2010L1. CD8<jats:sup>+<\/jats:sup> T cells, on the other hand, also enhanced their cytotoxicity towards target cells in response to OX40L expression on the DCs transferred in vivo. Finally, in a DC\u2010mediated tumor immunity model, the strong immunogenic roles of OX40L on DCs led to better metastasis inhibition in vivo. Collectively, our results demonstrate that OX40L could serve as a potential target in the DC\u2010based vaccine for enhanced anti\u2010tumor efficacy in vivo.<\/jats:p>","DOI":"10.1111\/1348-0421.13037","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T08:15:28Z","timestamp":1667895328000},"page":"79-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["OX40L enhances the immunogenicity of dendritic cells and inhibits tumor metastasis in mice"],"prefix":"10.1111","volume":"67","author":[{"given":"Lin","family":"Zhao","sequence":"first","affiliation":[{"name":"Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources, School of Life Sciences Anhui Normal University  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources, School of Life Sciences Anhui Normal University  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources, School of Life Sciences Anhui Normal University  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Jia","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources, School of Life Sciences Anhui Normal University  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources, School of Life Sciences Anhui Normal University  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengge","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources, School of Life Sciences Anhui Normal University  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-3982","authenticated-orcid":false,"given":"Yuekang","family":"Xu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory for Conservation and Exploitation of Biological Resources, School of Life Sciences Anhui Normal University  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.2.365"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90031-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.159.8.3838"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2019.11.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1427"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1436-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/1263053","article-title":"Yupingfeng granule improves Th2\u2010biased immune state in microenvironment of hepatocellular carcinoma through TSLP\u2010DC\u2010OX40L pathway","volume":"2020","author":"Yao F","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021290"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02279.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.1.486"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2991"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200010)30:10<2815::AID-IMMU2815>3.0.CO;2-#"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.11.6972"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181be7578"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.261933"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200708"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.6125"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108444"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.03120"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33307-z"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2017-0126"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.6.2723"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12051"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104049"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2018.06.001"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.823853"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12290"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.1.255"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493013"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051135"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4441"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(2002010)32:10<2874::AID-IMMU2874>3.0.CO;2-4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021937"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1839"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00766.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04791.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.4821"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4464"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3534"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2195"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.11.7969"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42388"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.661"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-070748"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.014"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.108"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090847"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344423"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.2160"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.11.7244"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.05.016"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071341"}],"container-title":["Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.13037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1348-0421.13037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1348-0421.13037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T01:14:49Z","timestamp":1692494089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1348-0421.13037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/1348-0421.13037"],"URL":"https:\/\/doi.org\/10.1111\/1348-0421.13037","archive":["Portico"],"relation":{},"ISSN":["0385-5600","1348-0421"],"issn-type":[{"value":"0385-5600","type":"print"},{"value":"1348-0421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]},"assertion":[{"value":"2022-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}