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The crosstalk between TAMs and HB cells markedly influences tumor behavior. TAM\u2010derived factors are involved in tumor proliferation and vascular invasion. On the other hand, HB cell secretome attracts, stimulates, and reprograms TAMs to be immunosuppressive in favor of tumor invasion, rather than their innate role in combating tumor growth, such crosstalk sometimes forms bidirectional feedback loops, making the tumor more virulent and resistant to routine therapeutics. Consequently, TAMs are the common denominator of most suggested HB immunotherapeutic strategies. Macrophage immune checkpoint inhibitors, macrophage\u2010mediated antibody\u2010dependent cellular phagocytosis, and the novel chimeric antigen receptor macrophage therapy (CAR M\u03c6) are currently under trial. In this review, we will summarize the significance of TAMs and their potential role as a therapeutic target in HB.<\/jats:p>","DOI":"10.1111\/1348-0421.13162","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T04:07:21Z","timestamp":1719374841000},"page":"249-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tumor\u2010associated macrophages: The key player in hepatoblastoma microenvironment and the promising therapeutic target"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-0123","authenticated-orcid":false,"given":"Ahmad","family":"Adawy","sequence":"first","affiliation":[{"name":"Department of Cell Pathology, Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"},{"name":"Department of Pediatric Surgery and Transplantation Kumamoto University Graduate School of Medical Sciences Kumamoto Japan"},{"name":"Department of Pediatric Surgery, Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9723-0846","authenticated-orcid":false,"given":"Yoshihiro","family":"Komohara","sequence":"additional","affiliation":[{"name":"Department of Cell Pathology, Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"},{"name":"Center for Metabolic Regulation of Healthy Aging Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizo","family":"Hibi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Transplantation Kumamoto University Graduate School of Medical Sciences Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.17998\/jlc.2022.02.24"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.11.002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/wjps-2020-000220"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12626"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.118268"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199510000-00014"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","unstructured":"KrijgsmanD KraaierL VerdonschotM SchubertS LeusenJHW DuikerEW et al. 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