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Here, we examined the effects of SARS\u2010CoV\u20102 (Omicron BA.5 strain) infection in a mouse model of airway allergy. First, stimulation of allergic mice with OVA resulted in the appearance of ACE2\u2010negative mucus\u2010secreting goblet cells in the bronchiolar region, and an increase in the number of ACE2\u2010expressing cells in the alveoli. As a result, ACE2\u2010expressing cells, which are susceptible to SARS\u2010CoV\u20102, were limited to the distal portion of the bronchioles while they increased in the alveolar area. After viral infection, the peak infectious viral load in the OVA group was 100\u2010fold lower than that in the phosphate buffered saline (PBS) group; however, clearance of viral RNA from the upper\/lower airways was delayed. There were notable differences in acquisition of nsp5 and nsp6 mutations by the Omicron BA.5 strain recovered from BALF samples obtained from the OVA and PBS groups. Immune responses associated with viral clearance were essentially the same, but expression of granulocyte\u2010associated chemokines was higher, M2 macrophage responses were predominant, and the higher spike\u2010specific IgG1\/IgG2a ratio in the OVA group post\u2010infection. Infection localized in the alveolar region earlier in the OVA group, resulting in more severe alveolar damage than in the PBS group. These data suggest a Th2\u2010shifted immune background and altered localization of SARS\u2010CoV\u20102 susceptible cells in mice with OVA\u2010induced airway allergy, which reflect Omicron BA.5 infection dynamics, viral mutations, and immunopathology.<\/jats:p>","DOI":"10.1111\/1348-0421.13184","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T05:03:15Z","timestamp":1732251795000},"page":"59-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Mouse Model of Ovalbumin\u2010Induced Airway Allergy Exhibits Altered Localization of SARS\u2010CoV\u20102\u2010Susceptible Cells in the Lungs, Which Reflects Omicron BA.5 Infection Dynamics, Viral Mutations, and Immunopathology"],"prefix":"10.1111","volume":"69","author":[{"given":"Takao","family":"Iketani","sequence":"first","affiliation":[{"name":"Department of Pathology National Institute of Infectious Diseases, Musashimurayama 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