{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:48:08Z","timestamp":1787161688845,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Sepsis\u2010associated acute kidney injury (AKI) poses a severe threat to patients' lives and health, making early predictions, intervention, and treatment crucial. This study aims to preliminarily explore the clinical role of miR\u2010577 and miR\u2010494\u20103p in sepsis\u2010associated AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The study included 70 sepsis patients with AKI, 65 sepsis patients without AKI, and a healthy control group (HC,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200967) to set baseline miRNA levels. Urinary miR\u2010577 and miR\u2010494\u20103p levels were measured using qRT\u2010PCR. ROC curves evaluated their diagnostic value for sepsis\u2010associated AKI. Logistic regression analyzed AKI risk factors, while Pearson correlation explored miRNA\u2010clinical indicator links. Cox regression models and KM curves assessed the prognostic value of miRNAs in sepsis\u2010associated AKI patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Sepsis\u2010associated AKI patients showed heightened inflammatory markers, renal indicators, and APACHE II scores compared to those without AKI. However, their urinary miR\u2010577 and miR\u2010494\u20103p levels were notably lower, distinguishing them with high diagnostic value. These miRNAs inversely correlated with inflammatory markers, renal indicators, and severity scores. Logistic regression showed lactate, PCT, BUN, Scr, Cys\u2010C, NGAL, KIM\u20101, and APACHE II, as risk factors, while miR\u2010577 and miR\u2010494\u20103p were protective. In deceased sepsis\u2010associated AKI patients, these miRNAs were lower, with higher inflammatory markers, renal indicators, and severity scores. miR\u2010577 and miR\u2010494\u20103p independently predicted mortality, with lower expressions linked to higher death rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>miR\u2010577 and miR\u2010494\u20103p are closely related to sepsis\u2010associated AKI and can serve as potential biomarkers for diagnosis and prognostic assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1348-0421.13210","type":"journal-article","created":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T12:43:47Z","timestamp":1742129027000},"page":"297-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring miR\u2010577 and miR\u2010494\u20103p as Emerging Biomarkers in Sepsis\u2010Associated Acute Kidney Injury: Diagnostic and Prognostic Perspectives"],"prefix":"10.1111","volume":"69","author":[{"given":"Lixia","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Oncology Nursing Hebei General Hospital Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingpo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Nursing Hebei General Hospital Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Nursing Hebei General Hospital Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Nursing Hebei General Hospital Hebei 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