{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:54:45Z","timestamp":1792176885933,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Lactiplantibacillus brownii<\/jats:italic>\n                    is a new species of lactic acid bacteria discovered in sauerkraut in Russia, first reported in 2023. We previously isolated\n                    <jats:italic>L. brownii<\/jats:italic>\n                    strain MH\u20101 (MH\u20101) from homemade pickled Chinese cabbage in Japan and reported that MH\u20101 prolonged healthspan and improved stress resistance in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    . In the present study, we investigated the effect of feeding MH\u20101 on resistance to infections in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    . MH\u20101 failed to increase its resistance to infection with\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    subsp.\n                    <jats:italic>aureus<\/jats:italic>\n                    (SA) and\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    (SE) at the adult stage. However, MH\u20101 feeding at the larval stage remarkably increased the survival rate of worms infected with SA, but not with SE. Genes related to the innate immune response were significantly upregulated by MH\u20101 feeding at the larval stage compared with those of the control group. A survival assay using loss\u2010of\u2010function mutants revealed that resistance to SA infection conferred by MH\u20101 feeding during the larval stage requires\n                    <jats:italic>daf\u201016<\/jats:italic>\n                    and\n                    <jats:italic>pmk\u20101<\/jats:italic>\n                    . These results suggest that MH\u20101 feeding at the larval stage likely confers resistance to SA infection by enhancing host immunity via the insulin\/insulin\u2010like growth factor 1 signaling and p38 mitogen\u2010activated protein kinase pathways.\n                  <\/jats:p>","DOI":"10.1111\/1348-0421.70020","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:10:49Z","timestamp":1762157449000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Administration of\n                    <i>Lactiplantibacillus brownii<\/i>\n                    Strain MH\u20101 During the Larval Stage Increases the Resistance Against\n                    <i>Staphylococcus aureus<\/i>\n                    subsp.\n                    <i>aureus<\/i>\n                    in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1111","volume":"70","author":[{"given":"Mina","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Graduate School of Human Life and Ecology Osaka Metropolitan University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-1331","authenticated-orcid":false,"given":"Yoshihiko","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Graduate School of Human Life and Ecology Osaka Metropolitan University Osaka Japan"},{"name":"Institute for Life and Medical Sciences Kyoto University Kyoto Japan"},{"name":"Graduate School of Biostudies Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Kage\u2010Nakadai","sequence":"additional","affiliation":[{"name":"Graduate School of Human Life and Ecology Osaka Metropolitan University Osaka Japan"},{"name":"Institute for Life and Medical Sciences Kyoto University Kyoto 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