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However, the molecular mechanisms underlying this process remain unclear. PDZD8 is an ER\u2010resident protein that mediates ER\u2013mitochondria contact and lipid transfer, both of which are associated with membrane remodeling. In this study, we found that WNV infection suppressed the expression of PDZD8, leading to a reduction in ER\u2013mitochondria contact sites. By contrast, PDZD8 suppressed WNV production by inhibiting the processes of viral particle assembly and release. These findings suggest that WNV suppresses PDZD8 expression to partially counteract its inhibitory effect on WNV production.<\/jats:p>","DOI":"10.1111\/1348-0421.70072","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:27:04Z","timestamp":1782732424000},"page":"474-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The ER\u2010Resident Protein PDZD8 Inhibits Virus Production of West Nile Virus"],"prefix":"10.1111","volume":"70","author":[{"given":"Shiori","family":"Abe","sequence":"first","affiliation":[{"name":"Laboratory of Public Health, Faculty of Veterinary Medicine Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari","family":"Sato","sequence":"additional","affiliation":[{"name":"Laboratory of Public Health, Faculty of Veterinary Medicine Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruto","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Public Health, Faculty of Veterinary Medicine Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Maezono","sequence":"additional","affiliation":[{"name":"Laboratory of Public Health, Faculty of Veterinary Medicine Hokkaido University Hokkaido Japan"},{"name":"Veterinary Research Unit, International Institute for Zoonosis Control Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Passawat","family":"Thammahakin","sequence":"additional","affiliation":[{"name":"Laboratory of Public Health, Faculty of Veterinary Medicine Hokkaido University Hokkaido Japan"},{"name":"Division of Molecular Pathobiology, International Institute for Zoonosis Control Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong Thi Ngoc","family":"Thuy","sequence":"additional","affiliation":[{"name":"Laboratory of Public Health, Faculty of Veterinary Medicine Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kariwa","sequence":"additional","affiliation":[{"name":"Laboratory of Public Health, Faculty of Veterinary Medicine Hokkaido University Hokkaido Japan"},{"name":"Veterinary Research Unit, International Institute for Zoonosis Control Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Public Health, Faculty of Veterinary Medicine Hokkaido University Hokkaido Japan"},{"name":"Veterinary Research Unit, International Institute for Zoonosis Control Hokkaido University Hokkaido Japan"},{"name":"Institute for Vaccine Research and Development (HU\u2010IVReD) Hokkaido University Hokkaido Japan"},{"name":"One Health Research Center Hokkaido University Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.ei10-0021-2016"},{"issue":"10","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1099\/0022-1317-79-10-2375","article-title":"West Nile Virus Envelope Proteins: Nucleotide Sequence Analysis of Strains Differing in Mouse Neuroinvasiveness","volume":"79","author":"Rice C. 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