{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:32:08Z","timestamp":1793233928787,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Knee osteoarthritis (KOA) is a chronic joint disorder characterized by cartilage deterioration. lacking disease\u2010modifying therapies. Aerobic exercise is recommended as a first\u2010line non\u2010pharmacological intervention for KOA, but its molecular mechanisms remain unclear. Recent studies indicate that the cyclic GMP\u2010AMP synthase (cGAS)\u2010stimulator of interferon genes (STING) pathway, a key regulator of inflammation and cartilage homeostasis, may mediate the protective effects of aerobic exercise on joint integrity. Male C57BL\/6 mice underwent destabilization of the medial meniscus (DMM) surgery and were assigned to Sham, Aerobic exercise, DMM, and DMM\u2009+\u2009Aerobic exercise groups. Aerobic treadmill running was performed for 4 weeks, with a STING agonist (DMXAA) and STING inhibitor (C\u2010176) used to verify pathway involvement. Joint function, cartilage histology, inflammatory cytokines, ECM metabolism, chondrocyte apoptosis, and cGAS\u2010STING pathway activation, including phosphorylation levels and 2\u20323\u2032\u2010cGAMP production, were assessed. DMM induced joint swelling, gait impairment, cartilage degradation, ECM catabolism, chondrocyte apoptosis, inflammation, and robust cGAS\u2010STING pathway activation. Aerobic exercise significantly ameliorated these changes, improving joint function, preserving cartilage and ECM integrity, reducing apoptosis, suppressing inflammatory cytokines, and directly inhibiting cGAS\u2010STING signaling. STING inhibition alone exerted comparable chondroprotective effects to aerobic exercise, and no additional benefit was observed in combination. DMXAA treatment abolished these protective effects. Aerobic exercise alleviates DMM\u2010induced knee osteoarthritis by enhancing joint function and preserving cartilage integrity, effects that are directly mediated through suppression of the cGAS\u2010STING pathway. These findings establish a causal link between aerobic exercise and innate immune regulation in osteoarthritis.<\/jats:p>","DOI":"10.1111\/1348-0421.70074","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:09:14Z","timestamp":1782904154000},"page":"416-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aerobic Exercise Mitigates Experimental Knee Osteoarthritis via Inhibition of cGAS\u2013STING Signaling"],"prefix":"10.1111","volume":"70","author":[{"given":"Yini","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Sports Medicine The Second People's Hospital of Hunan Province\/Brain Hospital of Hunan Province Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Sports Medicine The Second People's Hospital of Hunan Province\/Brain Hospital of Hunan Province Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Sports Medicine The Second People's Hospital of Hunan Province\/Brain Hospital of Hunan Province Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Sports Medicine The Second People's Hospital of Hunan Province\/Brain Hospital of Hunan Province Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Sports Medicine The Second People's Hospital of Hunan Province\/Brain Hospital of Hunan Province Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8801-0501","authenticated-orcid":false,"given":"Ke","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Sports Medicine The Second People's Hospital of Hunan Province\/Brain Hospital of Hunan Province Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21258"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216515"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.011"},{"issue":"10","key":"e_1_2_15_6_1","article-title":"A Comprehensive Review of Operative 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