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Certain fermented food components possess immunomodulatory effects. We previously showed that lactic acid bacteria (LAB) isolated from Nozawana\u2010zuke\u2014the traditional Japanese fermented\n                    <jats:italic>Brassica rapa<\/jats:italic>\n                    L. pickle\u2014activate immune function. Here we aimed to identify the LAB strain in fermented\n                    <jats:italic>B. rapa<\/jats:italic>\n                    L. that can markedly induce the expression of IL\u201015 mRNA in dendritic cells (DCs). We found that the\n                    <jats:italic>Levilactobacillus brevis<\/jats:italic>\n                    NZ3 strain isolated from\n                    <jats:italic>B. rapa<\/jats:italic>\n                    L. induces IL\u201015 production in DCs. We also provided mechanistic insight into the mechanism by which the NZ3 strain induces IL\u201015 production in DCs. We report that the NZ3 strain\u2010induced IL\u201015 production in DCs is mediated by Toll\u2010like receptor 3 signaling. Furthermore, inhibiting the interferon\u2010\u03b1\/\u03b2 receptor alpha chain abrogated the NZ3 strain\u2010induced IL\u201015 production. Further analysis using a Protein Kinase B (AKT) inhibitor revealed that the NZ3 strain\u2010induced IL\u201015 production is mediated by AKT signaling, which occurs downstream of Interferon\u2010\u03b1\/\u03b2 receptor signaling. Overall, our results indicate that the\n                    <jats:italic>Levilactobacillus brevis<\/jats:italic>\n                    NZ3 strain may serve as a potentially beneficial immunomodulatory bacterial strain. Moreover, due to its ability to induce IL\u201015 production, the NZ3 strain may serve as a candidate immunomodulatory strain for future studies.\n                  <\/jats:p>","DOI":"10.1111\/1348-0421.70080","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:57:52Z","timestamp":1784199472000},"page":"515-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <i>Levilactobacillus Brevis<\/i>\n                    NZ3 Isolated From Fermented\n                    <i>Brassica Rapa<\/i>\n                    L. Induces IL\u201015 Production in Dendritic Cells via Inducing IFN\u2010\u03b1"],"prefix":"10.1111","volume":"70","author":[{"given":"Akihiro","family":"Masaki","sequence":"first","affiliation":[{"name":"Department of Science and Technology, Graduate School of Medicine, Science and Technology Shinshu University  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumie","family":"Niitsuma","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Graduate School of Medicine, Science and Technology Shinshu University  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3666-430X","authenticated-orcid":false,"given":"Hiroka","family":"Sasahara","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Graduate School of Medicine, Science and Technology Shinshu University  Nagano 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