{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:01:48Z","timestamp":1786467708958,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07067"],"award-info":[{"award-number":["19K07067"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07017"],"award-info":[{"award-number":["20K07017"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K09864"],"award-info":[{"award-number":["24K09864"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Staphylococcus aureu<\/jats:italic>\n                    s is responsible for a wide range of pyogenic infections, food poisoning, and allergic inflammation.\n                    <jats:italic>S. aureus<\/jats:italic>\n                    produces a very wide variety of proteinaceous exotoxins, which are classified by structure as \u03b2\u2010barrel pore\u2010forming toxin, oligonucleotide\/oligosaccharide\u2010binding (OB)\u2010fold\/\u03b2\u2010grasp proteins, and triple\u2010helix bundle\u2010containing proteins. We previously reported that three staphylococcal exotoxins belonging to the first two groups activate basophils and mast cells, which are innate immune cells that play a central role in allergic inflammation. In this study, we focused on a group of triple\u2010helix bundle\u2010containing toxins and examined their ability to activate murine bone marrow\u2010derived mast cells and basophils. Extracellular complement\u2010binding protein (Ecb), previously known as a complement inhibitor, was found to induce IL\u20104 and IL\u20106 production in basophils but not that of IL\u20106 and IL\u201013 in mast cells. Ecb did not induce IL\u20104 production in murine splenocytes or CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, suggesting that it is a basophil\u2010specific activator. Ecb\u2010induced IL\u20104 expression in basophils in the absence of serum. The C3\u2010binding\u2010deficient mutant of Ecb also activated basophils, indicating that Ecb activates basophils independently of its complement\u2010inhibiting activity. Dasatinib, a Src kinase inhibitor, prevented Ecb\u2010induced IL\u20104 production in basophils, suggesting that the activation required a Src family kinase. These findings reveal a novel function of Ecb, that is, the activation of basophils to produce IL\u20104 in an IgE\u2010independent manner, and suggest a dual Ecb contribution to immune evasion\u2014by interfering with complement activation and skewing Th2 immunity\u2014and a role in the development of allergic inflammation\u2014by inducing IL\u20104 production.\n                  <\/jats:p>","DOI":"10.1111\/1348-0421.70086","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:26:36Z","timestamp":1786465596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Staphylococcal Extracellular Complement\u2010Binding Protein Induces IL\u20104 Production in Murine Basophils"],"prefix":"10.1111","author":[{"given":"Haruka","family":"Sakakibara","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Japan"},{"name":"Laboratory of Hygienic Chemistry, School of Pharmacy Aichi Gakuin University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shion","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Japan"},{"name":"Laboratory of Hygienic Chemistry, School of Pharmacy Aichi Gakuin University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikuto","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Kiriyama","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneshige","family":"Tokugawa","sequence":"additional","affiliation":[{"name":"Laboratory of Hygienic Chemistry, School of Pharmacy Aichi Gakuin University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-9430","authenticated-orcid":false,"given":"Shigeaki","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5704-0543","authenticated-orcid":false,"given":"Saotomo","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Japan"},{"name":"Laboratory of Hygienic Chemistry, School of Pharmacy Aichi Gakuin University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0091-6749(99)70390-8","article-title":"Evaluation of the Staphylococcal Exotoxins and Their Specific IgE in Childhood Atopic Dermatitis","volume":"104","author":"Nomura I.","year":"1999","journal-title":"Journal of Allergy and Clinical 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