{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:56:51Z","timestamp":1791284211457,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbiology and Immunology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    is one of the etiologic agents of whooping cough and its incidence has increased following the COVID\u201019 pandemic. Since current pertussis vaccines fail to induce protection against\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    , the course of infection critically relies on the innate immune response. However, in the absence of opsonic antibodies,\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    fails to activate resting neutrophils, thereby preventing bactericidal responses. We here investigated whether neutrophil priming with gamma\u2010interferon (IFN\u2010\u03b3), the main proinflammatory cytokine present during infection, changes this outcome. We observed that IFN\u2010\u03b3\u2010 priming of neutrophils did not enhance extracellular nor intracellular bactericidal mechanisms against\n                    <jats:italic>B. parapertussi<\/jats:italic>\n                    s. Human neutrophils remain basically unresponsive to this pathogen despite IFN\u2010\u03b3 priming, and this lack of activation proved independent of adenylate cyclase toxin (CyaA), the immunomodulatory toxin produced by\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    . Collectively, our findings demonstrate that\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    does not trigger neutrophil activation, irrespective of the inflammatory context. This ability to evade a key arm of the innate immune response likely constitutes a critical pathogenic trait that, particularly in the absence of cross\u2010protection conferred by current pertussis vaccines, underlies persistent infections and the continued circulation of the pathogen.\n                  <\/jats:p>","DOI":"10.1111\/1348-0421.70094","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:48:33Z","timestamp":1791283713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Bordetella parapertussis<\/i>\n                    Evades Neutrophil\u2010Mediated Killing by Failing to Trigger Innate Activation Even After IFN\u2010\u03b3 Priming"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1944-0631","authenticated-orcid":false,"given":"Carlos Manuel","family":"Baroli","sequence":"first","affiliation":[{"name":"CINDEFI (UNLP CONICET La Plata), Facultad de Ciencias Exactas Universidad Nacional de La Plata La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6412-1774","authenticated-orcid":false,"given":"Juan Pablo","family":"Gorgojo","sequence":"additional","affiliation":[{"name":"CINDEFI (UNLP CONICET La Plata), Facultad de Ciencias Exactas Universidad Nacional de La Plata La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-8763","authenticated-orcid":false,"given":"Mariela del Carmen","family":"Carrica","sequence":"additional","affiliation":[{"name":"CINDEFI (UNLP CONICET La Plata), Facultad de Ciencias Exactas Universidad Nacional de La Plata La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-428X","authenticated-orcid":false,"given":"Maria Eugenia","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"CINDEFI (UNLP CONICET La Plata), Facultad de Ciencias Exactas Universidad Nacional de La Plata La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3235"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2.3.447"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir860"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001843"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid3005.231278"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.11.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006989"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1128\/iai.61.2.486-490.1993","article-title":"Bordetella pertussis and 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