{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:14:10Z","timestamp":1777583650225,"version":"3.51.4"},"reference-count":90,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KA2910\/1\u20102"],"award-info":[{"award-number":["KA2910\/1\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["besjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Animal Ecology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:list><jats:list-item><jats:p>Parasites are important selective agents with the potential to limit gene flow between host populations by shaping local host immunocompetence.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>We report on a contact zone between lake and river three\u2010spined sticklebacks (<jats:italic>Gasterosteus aculeatus<\/jats:italic>) that offers the ideal biogeographic setting to explore the role of parasite\u2010mediated selection on reproductive isolation. A waterfall acts as a natural barrier and enforces unidirectional migration from the upstream river stickleback population to the downstream river and lake populations.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>We assessed population genetic structure and parasite communities over four years. In a set of controlled experimental infections, we compared parasite susceptibility of upstream and downstream fish by exposing laboratory\u2010bred upstream river and lake fish, as well as hybrids, to two common lake parasite species: a generalist trematode parasite,<jats:italic>Diplostomum pseudospathaceum<\/jats:italic>, and a host\u2010specific cestode,<jats:italic>Schistocephalus solidus<\/jats:italic>.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>We found consistent genetic differentiation between upstream and downstream populations across four sampling years, even though the downstream river consisted of ~10% first\u2010generation migrants from the upstream population as detected by parentage analysis. Fish in the upstream population had lower genetic diversity and were strikingly devoid of macroparasites. Through experimental infections, we demonstrated that upstream fish and their hybrids had higher susceptibility to parasite infections than downstream fish. Despite this, naturally sampled upstream migrants were less infected than downstream residents. Thus, migrants coming from a parasite\u2010free environment may enjoy an initial fitness advantage, but their descendants seem likely to suffer from higher parasite loads.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Our results suggest that adaptation to distinct parasite communities can influence stickleback invasion success and may represent a barrier to gene flow, even between close and connected populations.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1111\/1365-2656.13080","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T14:53:17Z","timestamp":1564584797000},"page":"1986-1997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Examining the role of parasites in limiting unidirectional gene flow between lake and river sticklebacks"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-0954","authenticated-orcid":false,"given":"No\u00e9mie I.","family":"Erin","sequence":"first","affiliation":[{"name":"Department of Evolutionary Ecology Max Planck Institute for Evolutionary Biology Pl\u00f6n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4572-9546","authenticated-orcid":false,"given":"Daniel P.","family":"Benesh","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Humboldt University Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Henrich","sequence":"additional","affiliation":[{"name":"Department of Evolutionary Ecology Max Planck Institute for Evolutionary Biology Pl\u00f6n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-5230","authenticated-orcid":false,"given":"Irene E.","family":"Samonte","sequence":"additional","affiliation":[{"name":"Department of Evolutionary Ecology Max Planck Institute for Evolutionary Biology Pl\u00f6n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per J.","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Biology University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kalbe","sequence":"additional","affiliation":[{"name":"Department of Evolutionary Ecology Max Planck Institute for Evolutionary Biology Pl\u00f6n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12158"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00265-003-0611-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2664.2003.00841.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-323"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2001)087[0250:DCITCO]2.0.CO;2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1420-9101.2008.01583.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2009.00665.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182012001527"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2004.tb01683.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2009.00699.x"},{"key":"e_1_2_11_13_1","first-page":"575","article-title":"Effects of colonization history and landscape structure on genetic variation within and among threespine stickleback (Gasterosteus aculeatus) populations in a single watershed","volume":"10","author":"Caldera E. J.","year":"2008","journal-title":"Evolutionary Ecology Research"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1163\/1568539055010129"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2005.02764.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2011.01388.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12686-011-9548-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10682-010-9424-z"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2016.0691"},{"key":"e_1_2_11_20_1","article-title":"Data from: Examining the role of parasites in limiting unidirectional gene flow between lake and river sticklebacks","author":"Erin N. I.","year":"2019","journal-title":"Dryad Digital Repository"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200008015X"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-0998.2010.02847.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1645\/GE-451R.1"},{"key":"e_1_2_11_24_1","article-title":"Genomics of divergence along a continuum of parapatric population differentiation","volume":"11","author":"Feulner P. G. D.","year":"2015","journal-title":"PLoS Genetics"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2656.2001.00524.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-8286.2004.00597.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043129"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2006.02825.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1420-9101.2007.01427.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ecolsys.36.102003.152622"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1795.2006.00059.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jeb.12978"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2009.02419.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2002.tb01432.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm233"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jeb.13035"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1420-9101.2006.01122.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2008.1466"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182005008681"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2002.tb02445.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130579"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/280169"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jeb.13057"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ecy.1953"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2003.2567"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-8286.2005.01031.x"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5347(02)02497-7"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v069.i01"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2004.2752"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0706.2000.880110.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2010.08.013"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2435.2010.01691.x"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2009.02411.x"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2004.tb01577.x"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2005.tb01747.x"},{"key":"e_1_2_11_56_1","unstructured":"Oksanen J. Blanchet F. G. Friendly M. Kindt R. Legendre P. McGlinn D. \u2026Wagner H.(2019).vegan: Community Ecology Package. R package version 2.5-4."},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.13345"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/414901a"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esh074"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0587.2010.06826.x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2004.02396.x"},{"key":"e_1_2_11_62_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2018"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-13-41"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122825"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/35104547"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0962-1083.2001.01366.x"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-8286.2003.00566.x"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-8286.2007.01931.x"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.1996.tb01434.x"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1461-0248.2004.00715.x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2036360100"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-109"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2007.0210"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2007.1148"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2002.2265"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5347(02)00013-7"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2018.2147"},{"key":"e_1_2_11_78_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1242\/jeb.23.1.47","article-title":"Studies on tapeworm physiology, the cultivation of Schistocephalus solidus in vitro","volume":"23","author":"Smyth D. J.","year":"1946","journal-title":"The Journal of Experimental Biology"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2006.0198"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2005.02794.x"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182007000248"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2005.02773.x"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-8286.2004.00684.x"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2000.tb00707.x"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-210X.2012.00190.x"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00265-005-0143-3"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182097001406"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0001066X"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1461-0248.2003.00419.x"},{"key":"e_1_2_11_90_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/oso\/9780198506201.003.0002","article-title":"Heterogeneities in macroparasite infections: Patterns and processes","volume":"44","author":"Wilson K.","year":"2002","journal-title":"The Ecology of Wildlife Diseases"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1978.tb04178.x"}],"container-title":["Journal of Animal Ecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1365-2656.13080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1365-2656.13080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/besjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1365-2656.13080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T15:06:48Z","timestamp":1721574408000},"score":1,"resource":{"primary":{"URL":"https:\/\/besjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1365-2656.13080"}},"subtitle":[],"editor":[{"given":"Christophe","family":"Eizaguirre","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,26]]},"references-count":90,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/1365-2656.13080"],"URL":"https:\/\/doi.org\/10.1111\/1365-2656.13080","archive":["Portico"],"relation":{},"ISSN":["0021-8790","1365-2656"],"issn-type":[{"value":"0021-8790","type":"print"},{"value":"1365-2656","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,26]]},"assertion":[{"value":"2018-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}