{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:47:32Z","timestamp":1764874052273,"version":"3.40.5"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,9]],"date-time":"2023-04-09T00:00:00Z","timestamp":1680998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2016\u201004240"],"award-info":[{"award-number":["2016\u201004240"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["besjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Animal Ecology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n<jats:list>\n\n<jats:list-item><jats:p>In winter, a challenge to the immune system could pose a major energetic trade\u2010off for small endotherms, whereby increasing body temperature (<jats:italic>T<\/jats:italic><jats:sub>b<\/jats:sub>; i.e. eliciting fever) may be beneficial to fight off invading pathogens yet incur a cost for vital energy\u2010saving mechanisms.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Having previously shown that the availability and acquisition of energy, through manipulation of food predictability, influences the depth of rest\u2010phase hypothermia in a wild bird in winter, we expected that the nocturnal thermoregulatory component of the acute\u2010phase immune response would also be modulated by food availability.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>By manipulating winter food availability in the wild for great tits <jats:italic>Parus major<\/jats:italic>, we created an area offering a \u201cpredictable\u201d and constant supply of food at feeding stations, while an unmanipulated area was subject to naturally \u201cunpredictable\u201d food. Birds were subject to an immune challenge shortly after dusk, and the thermoregulatory response was quantified via continuous recording of nocturnal <jats:italic>T<\/jats:italic><jats:sub>b<\/jats:sub>, using subcutaneous thermo\u2010sensitive transponders.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>In response to immune challenge, all birds increased <jats:italic>T<\/jats:italic><jats:sub>b<\/jats:sub> above the level maintained prior to immune challenge (i.e. baseline). However, birds experiencing a naturally unpredictable food supply elevated <jats:italic>T<\/jats:italic><jats:sub>b<\/jats:sub> more than birds subject to predictable food resources, during the period of expected peak response and for the duration of the night. Furthermore, \u201cunpredictable\u2010food\u201d females took longer to return to their baseline <jats:italic>T<\/jats:italic><jats:sub>b<\/jats:sub>. Assuming baseline nocturnal <jats:italic>T<\/jats:italic><jats:sub>b<\/jats:sub> reflects an individual's optimum, based on their available energy budget, the metabolic cost of eliciting an acute\u2010phase response for \u201cunpredictable\u2010food\u201d birds was more than double that of \u201cpredictable\u2010food\u201d birds. The absence of differences in absolute <jats:italic>T<\/jats:italic><jats:sub>b<\/jats:sub> during the peak response could support the idea of an optimal <jats:italic>T<\/jats:italic><jats:sub>b<\/jats:sub> for immune system activation. Alternatively, \u201cpredictable\u2010food\u201d birds could have acquired tolerance to endotoxin as a result of using feeding stations, thus affording them reduced costs associated with a smaller <jats:italic>T<\/jats:italic><jats:sub>b<\/jats:sub> increase.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>These findings shed new light on the trade\u2010offs associated with food acquisition, thermoregulation and immune function in small\u2010bodied endotherms. This knowledge is of increasing importance, given the predicted elevated pathogen risks associated with changes in climate and anthropogenic activities.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/1365-2656.13914","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T04:01:05Z","timestamp":1681099265000},"page":"1065-1074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thermoregulatory costs of the innate immune response are modulated by winter food availability in a small passerine"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-0647","authenticated-orcid":false,"given":"Hannah","family":"Watson","sequence":"first","affiliation":[{"name":"Evolutionary Ecology Lund University  Lund SE\u2010223 62 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8982-1064","authenticated-orcid":false,"given":"Jan\u2010\u00c5ke","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Evolutionary Ecology Lund University  Lund SE\u2010223 62 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-6486","authenticated-orcid":false,"given":"Johan F.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Evolutionary Ecology Lund University  Lund SE\u2010223 62 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102435.2010.01702.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2015.1429"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1890\/04\u20101619"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01948375"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102656.12765"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/09680519030090010101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2001.1915"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.7.8922"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icu046"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/588591"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.027011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049124104268644"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102435.2010.01815.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5055"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/689913"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/701389"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5452.443"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079450701286277"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00377.2005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010012\u20100718\u2010z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0621553"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003600050225"},{"issue":"1","key":"e_1_2_10_24_1","first-page":"38","article-title":"The evolution and adaptive value of fever: Long regarded as a harmful by\u2010product of infection, fever may instead be an ancient ally against disease, enhancing resistance and increasing chances of survival","volume":"66","author":"Kluger M. J.","year":"1978","journal-title":"American Scientist"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1991.71.1.93"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102664.13567"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102435.2009.01628.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0908\u20108857.2006.03632.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10393\u2010017\u20101261\u2010x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2010.12.004"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.056499"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74078-7_6"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/condor\/104.4.705"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8013"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2020.0133"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102435.12003"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.219287"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00442\u2010011\u20101972\u20106"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/beheco\/11.1.19"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10164\u2010008\u20100092\u20101"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02371"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10336\u2010007\u20100197\u20102"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00562.2001"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102249.2009.04052.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010196501000\u201000022"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2741\/1690"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020182"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2004.06.005"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169\u20105347(96)10039\u20102"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.122150"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691712"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2007.2145"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.5061\/dryad.73n5tb326"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246\u2010200201001\u201000009"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/conphys\/cov058"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/42.3.600"}],"container-title":["Journal of Animal Ecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/besjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1365-2656.13914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:30:34Z","timestamp":1692631834000},"score":1,"resource":{"primary":{"URL":"https:\/\/besjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1365-2656.13914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,9]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/1365-2656.13914"],"URL":"https:\/\/doi.org\/10.1111\/1365-2656.13914","archive":["Portico"],"relation":{},"ISSN":["0021-8790","1365-2656"],"issn-type":[{"type":"print","value":"0021-8790"},{"type":"electronic","value":"1365-2656"}],"subject":[],"published":{"date-parts":[[2023,4,9]]},"assertion":[{"value":"2022-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}