{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:18:10Z","timestamp":1790410690804,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\n<jats:list>\n\n<jats:list-item><jats:p> Heightened sympathetic activity plays a role in the cardiovascular sequelae of obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>). Cardiac autonomic function may be assessed non\u2010invasively by studying heart rate variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>). The aim of the present study was to compare overnight <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> between a control group and a group of subjects with severe <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>. The potential confounding effects of age, sex, baseline autonomic status and sleep stage distribution were taken into account.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p> Our prospective Holter study compared overnight (0030\u20130530\u00a0hours) <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> in 23 controls (apnoea hypopnoea index (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>)\u00a0=\u00a05\u00a0\u00b1\u00a03\u00a0\/h) and 23 subjects with severe <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> = 65\u00a0\u00b1\u00a023\u00a0\/h), matched for age and sex and with a similar percentage of rapid eye movement sleep.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p> The mean normal\u2010to\u2010normal RR interval (NN) was shorter in the OSA compared with control group (903 <jats:italic>vs<\/jats:italic> 1039\u00a0ms, respectively), whereas the other time\u2010domain indices of HRV, as well as the classic frequency\u2010domain indices, were similar. Essentially similar results were obtained hourly and when only subjects with high mean values of the standard deviation of all NN (\u2265\u00a090\u00a0ms) were evaluated. In the 0.01\u20130.06\u00a0Hz range corresponding to the typical OSA pattern of bradycardia\u2013tachycardia termed cyclic variation of heart rate (CVHR), higher power was documented hourly in OSA, with a significant correlation between overnight power and both AHI and mean oxyhaemoglobin saturation. The percentage of NN &gt;\u00a0<jats:italic>x<\/jats:italic>\u00a0ms different from the previous one (<jats:styled-content style=\"fixed-case\">pNN<\/jats:styled-content><jats:italic>x<\/jats:italic> family) had no diagnostic value.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p> The results of the present study suggest that <jats:styled-content style=\"fixed-case\">NN<\/jats:styled-content> may be the best index to quantify the overnight sympathovagal balance in <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> and that a spectral band overlapping the apnoea\u2010related pattern of <jats:styled-content style=\"fixed-case\">CVHR<\/jats:styled-content> slightly improved the characterization of the apnoea\u2010related <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> patterns.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/1440-1681.12012","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T02:27:07Z","timestamp":1348540027000},"page":"901-908","source":"Crossref","is-referenced-by-count":31,"title":["Overnight heart rate variability in patients with obstructive sleep apnoea: A time and frequency domain study"],"prefix":"10.1111","volume":"39","author":[{"given":"Kaixian","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Physiology Sleep Laboratory Antoine\u2010B\u00e9cl\u00e8re Hospital Clamart France"},{"name":"EA4533\u2010APHP Faculty of Medicine University of Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Chemla","sequence":"additional","affiliation":[{"name":"EA4533\u2010APHP Faculty of Medicine University of Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Roisman","sequence":"additional","affiliation":[{"name":"Department of Physiology Sleep Laboratory Antoine\u2010B\u00e9cl\u00e8re Hospital Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Physiology Sleep Laboratory Antoine\u2010B\u00e9cl\u00e8re Hospital Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Bazizi","sequence":"additional","affiliation":[{"name":"Department of Physiology Sleep Laboratory Antoine\u2010B\u00e9cl\u00e8re Hospital Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaury","family":"Lefevre","sequence":"additional","affiliation":[{"name":"Department of Physiology Sleep Laboratory Antoine\u2010B\u00e9cl\u00e8re Hospital Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Escourrou","sequence":"additional","affiliation":[{"name":"Department of Physiology Sleep Laboratory Antoine\u2010B\u00e9cl\u00e8re Hospital Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"132","article-title":"Cardiac autonomic activity in obstructive sleep apnea: Time\u2010dependent and spectral analysis of heart rate variability using 24\u2010hour Holter electrocardiograms","volume":"31","author":"Aydin M","year":"2004","journal-title":"Tex. 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