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Such overnutrition can occur in the offspring of obese mothers, the offspring of mothers who gain excess weight during gestation, infants of diabetic mothers and infants who undergo rapid growth, particularly weight gain, during early infancy. Postnatal overnutrition is particularly detrimental for infants who are born small for gestational age, who are overfed to attain \u2018catch\u2010up growth\u2019.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Potential mechanisms underlying metabolic programming that results from excess nutrition during early life include resetting of hypothalamic energy sensing and appetite regulation, altered adipose tissue insulin sensitivity and impaired brown adipose tissue function.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p> More detailed understanding of the mechanisms involved in metabolic programming could enable the development of therapeutic strategies for ameliorating its ill effects. Research in this field could potentially identify optimal and appropriate preventative interventions for a burgeoning population at risk of increased mortality and morbidity from obesity and its concomitant metabolic conditions.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/1440-1681.12061","type":"journal-article","created":{"date-parts":[[2013,1,26]],"date-time":"2013-01-26T07:34:28Z","timestamp":1359185668000},"page":"817-823","source":"Crossref","is-referenced-by-count":34,"title":["Excess nutrient supply in early life and its later metabolic consequences"],"prefix":"10.1111","volume":"40","author":[{"given":"Shalini","family":"Ojha","sequence":"first","affiliation":[{"name":"The Early Life Nutrition Research Unit Academic Division of Child Health School of Clinical Sciences University Hospital The University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Saroha","sequence":"additional","affiliation":[{"name":"The Early Life Nutrition Research Unit Academic Division of Child Health School of Clinical Sciences University Hospital The University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Symonds","sequence":"additional","affiliation":[{"name":"The Early Life Nutrition Research Unit Academic Division of Child Health School of Clinical Sciences University Hospital The University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Budge","sequence":"additional","affiliation":[{"name":"The Early Life Nutrition Research Unit Academic Division of Child Health School of Clinical Sciences University Hospital The University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,27]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"The Health Survey for England, 2006","author":"Department of Health","year":"2008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00991.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.250"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000278819.17190.87"},{"key":"e_1_2_7_6_1","volume-title":"Maternal Obesity in the UK: Findings from a National Project","author":"Centre for Maternal and Child Enquiries (CMACE)","year":"2010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6809.1019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.91019.2008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.079756"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/ajcn\/44.6.986","article-title":"The 1986 McCollum Award Lecture. 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