{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:35:16Z","timestamp":1697603716398},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\n<jats:list>\n\n<jats:list-item><jats:p>It has been shown that acromegaly is characterized by an autonomic imbalance and by marked sympathoinhibition. However, there is no information available as to whether adrenergic inhibition is confined to selected vascular districts or, rather, is generalized.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>We examined 17 newly diagnosed active acromegalic patients without hyperprolactinaemia, pituitary hormone deficiencies, obstructive sleep apnoea and cardiac hypertrophy and 14 healthy subjects matched for age, sex and body mass index. For each subject, we collected information regarding anthropometric parameters and echocardiography, and collected plasma samples to investigate anterior pituitary function, glucose and lipid metabolism and plasma leptin levels.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Beat\u2010to\u2010beat mean arterial pressure, heart rate and efferent post\u2010ganglionic muscle and skin sympathetic nerve traffic (<jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SSNA<\/jats:styled-content>, respectively; determined by microneurography) were measured. Both <jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SSNA<\/jats:styled-content> were recorded in a randomized sequence over two 30\u00a0min periods. Measurements also included evaluation of <jats:styled-content style=\"fixed-case\">SSNA<\/jats:styled-content> responses to emotional stimulus.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>In addition to significant reductions in plasma leptin levels, acromegalic patients had markedly decreased <jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content> compared with the healthy controls. There were no significant differences in <jats:styled-content style=\"fixed-case\">SSNA<\/jats:styled-content> between the two groups, either under basal conditions or in responses to arousal stimuli. There was a significant and direct correlation between <jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content> and plasma leptin levels, but not between plasma leptin and <jats:styled-content style=\"fixed-case\">SSNA<\/jats:styled-content>.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>These data provide the first evidence that the sympathetic inhibition characterizing the early phase of acromegaly is not generalized to the entire cardiovascular system.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/1440-1681.12082","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T07:12:39Z","timestamp":1364281959000},"page":"333-337","source":"Crossref","is-referenced-by-count":1,"title":["Differential patterns of regional neuroadrenergic cardiovascular drive in acromegalic disease"],"prefix":"10.1111","volume":"40","author":[{"given":"Gino","family":"Seravalle","sequence":"first","affiliation":[{"name":"Cardiology Department St. Luca Hospital Istituto Auxologico Italiano Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Carzaniga","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medical Sciences St. Luca Hospital Istituto Auxologico Italiano University of Milan Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Sciortino","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medical Sciences St. Luca Hospital Istituto Auxologico Italiano University of Milan Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Attanasio","sequence":"additional","affiliation":[{"name":"Endocrinology Istituto Galeazzi Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia Maria","family":"Fatti","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medical Sciences St. Luca Hospital Istituto Auxologico Italiano University of Milan Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Ospedale Niguarda Ca'Granda Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Montini","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Ospedali Riuniti Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Vitale","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medical Sciences St. Luca Hospital Istituto Auxologico Italiano University of Milan Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianmaria","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Clinica Medica Department of Clinical Medicine and Prevention University of Milano Bicocca Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cavagnini","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrinology Istituto Auxologico Italiano Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Mancia","sequence":"additional","affiliation":[{"name":"Clinica Medica Department of Clinical Medicine and Prevention University of Milano Bicocca Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Grassi","sequence":"additional","affiliation":[{"name":"Clinica Medica Department of Clinical Medicine and Prevention University of Milano Bicocca Monza Italy"},{"name":"Multimedica Sesto San Giovanni Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Scacchi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medical Sciences St. Luca Hospital Istituto Auxologico Italiano University of Milan Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-201X.2004.01368.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2004.12.007"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917060-00001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1506"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04335.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200310000-00018"},{"key":"e_1_2_5_8_1","first-page":"CR685","article-title":"Serum leptin levels in acromegaly: A significant role for adipose tissue and fasting insulin\/glucose ratio","volume":"8","author":"Bolanowski M","year":"2002","journal-title":"Med. 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