{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:14:47Z","timestamp":1758924887290,"version":"3.40.4"},"reference-count":94,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T00:00:00Z","timestamp":1382832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:list><jats:list-item><jats:p>\u00a0The renin\u2013angiotensin system (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) plays a critical role in placentation and nephrogenesis. Failure to thrive during intrauterine life, possibly related to placental dysfunction and impaired expression of the renal<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>, as well as prematurity, results in smaller kidneys at birth and reduced nephron number. The remaining nephrons are therefore hyperfiltering from birth. Hyperfiltration, infections and Type 2 diabetes cause glomerular and tubular fibrosis, leading to further reductions in nephron number.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>\u00a0The intrarenal<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>plays a key role in promoting tubulointerstitial fibrosis. Low birth weight and a high incidence of preterm birth program Indigenous children for early onset renal disease in adult life. Indigenous Australians have 404\u00a0000 fewer nephrons than non\u2010Indigenous Australians. This, coupled with the high incidence of infectious diseases (particularly acute post\u2010streptococcal glomerulonephritis) and the increasing prevalence of Type 2 diabetes, explains why end\u2010stage renal disease is of epidemic proportions in Indigenous Australians.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>\u00a0The existence of<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>gene polymorphisms and inflammatory cytokines may further potentiate susceptibility to renal disease in Indigenous Australians.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1111\/1440-1681.12098","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T01:55:57Z","timestamp":1382925357000},"page":"743-752","source":"Crossref","is-referenced-by-count":13,"title":["The renin\u2013angiotensin system from conception to old age: the good, the bad and the ugly"],"prefix":"10.1111","volume":"40","author":[{"given":"Eugenie R","family":"Lumbers","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy Hunter Medical Research Institute University of Newcastle and Mothers and Babies Research Centre Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsty G","family":"Pringle","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy Hunter Medical Research Institute University of Newcastle and Mothers and Babies Research Centre Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy Hunter Medical Research Institute University of Newcastle and Mothers and Babies Research Centre Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen J","family":"Gibson","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2011.11.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010121266"},{"key":"e_1_2_8_4_1","article-title":"Relationships between glomerular filtration rate and kidney Volume in low\u2010birth\u2010weight neonates","author":"Kandasamy Y","year":"2012","journal-title":"J. Nephrol."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10010022.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13726.x"},{"key":"e_1_2_8_7_1","unstructured":"HealthInfoNet.Review of the Kidney Health of Indigenous Peoples.2006. Available from:http:\/\/www.healthinfonet.ecu.edu.au\/chronic-conditions\/kidney\/reviews\/our-review2006(accessed 29 March 2013)."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.678342"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-012-6424-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13376.x"},{"key":"e_1_2_8_11_1","first-page":"329","article-title":"Activation of renin in human amniotic fluid by low pH","volume":"40","author":"Lumbers ER","year":"1971","journal-title":"Enzymologia"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(72)90090-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214276"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100432"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","article-title":"International Union of pharmAcology. XXIII. The angiotensin II receptors","volume":"52","author":"Gasparo M","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0341"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120461"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07830.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2008.02.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00838-X"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys116"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90552-2"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.1275"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-07-0374"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1681\/ASN.V102245","article-title":"Angiotensin II stimulates the synthesis and secretion of vascular permeability factor\/vascular endothelial growth factor in human mesangial cells","volume":"10","author":"Pupilli C","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000017372.76297.EB"},{"key":"e_1_2_8_27_1","first-page":"4176","article-title":"Angiotensin II type I antagonist prevents pulmonary metastasis of murine renal cancer by inhibiting tumor angiogenesis","volume":"62","author":"Miyajima A","year":"2002","journal-title":"Cancer Res."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240540107"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00190-9"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1210\/endo.141.3.7367","article-title":"Pregnancy\u2010dependent changes in cell signaling underlie changes in differential control of vasodilator production in uterine artery endothelial cells","volume":"141","author":"Bird IM","year":"2000","journal-title":"Endocrinology"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.23.10479-10491.2005"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.07.006"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0161"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2945"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh236"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22540"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.09.020"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1978.2"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.05.001"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.12.018"},{"key":"e_1_2_8_41_1","first-page":"S421","article-title":"Role of cyclic AMP in renin secretion by human transfected juxtaglomerular cells","volume":"4","author":"Pinet F","year":"1986","journal-title":"J. Hypertens. Suppl."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(05)80418-7"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000258855.60637.58"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.068213"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01152.2007"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.11.004"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719110385134"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64849-3"},{"key":"e_1_2_8_49_1","first-page":"F110","article-title":"Angiotensin II regulates nephrogenesis and renal vascular development","volume":"269","author":"Tufro\u2010McReddie A","year":"1995","journal-title":"Am. J. Physiol."},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8513"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00426.2003"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00134-0"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.6.1099"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200104000-00005"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13886.x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00526.x"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2011.01.009"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000135678.20725.54"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.105.063636"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.001"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00305.2011"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313363"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000175814.18550.c0"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00101.2009"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.042085"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006040356"},{"key":"e_1_2_8_67_1","first-page":"2526","article-title":"Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney","volume":"118","author":"Toma I","year":"2008","journal-title":"J. Clin. Invest."},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2008.04.008"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.123802"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2011.00172.x"},{"key":"e_1_2_8_71_1","first-page":"108","article-title":"Urinary angiotensinogen as a novel biomarker of intrarenal renin\u2013angiotensin system in chronic kidney disease","volume":"6","author":"Kobori H","year":"2011","journal-title":"Int. Rev. Thromb."},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000286037"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.12076FP"},{"key":"e_1_2_8_74_1","unstructured":"HealthInfoNet.Births and Pregnancy Outcome.2006. Available from:http:\/\/www.healthinfonet.ecu.edu.au\/health-facts\/overviews\/births-and-pregnancy-outcome(accessed 29 March 2013)."},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2010.01124.x"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000397"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20651"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00793.x"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91175-C"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607253350402"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.408"},{"key":"e_1_2_8_82_1","unstructured":"HealthInfoNet.Review of Diabetes among Indigenous Peoples.2007. Available from:http:\/\/www.healthinfonet.ecu.edu.au\/chronic-conditions\/diabetes\/reviews\/our-review accessed 29 March 2013."},{"key":"e_1_2_8_83_1","unstructured":"Prime Minister's Science Engineering and Innovation Council (PMSEIC) Working Group on Aboriginal and Islander Health Focusing on Maternal Fetal and Postnatal Health.The Health of the Adult Begins in the Womb. A Report of the PMSEIC Working Group April 2008.2008. Available from:http:\/\/www.innovation.gov.au\/Science\/PMSEIC\/Documents\/AboriginalandTorresStraitIslandHealth.pdf accessed 29 March 2013."},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.4.887"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315866"},{"key":"e_1_2_8_86_1","first-page":"3238","article-title":"Genetic polymorphisms of the renin\u2013angiotensin\u2013aldosterone system in Chinese patients with end\u2010stage renal disease secondary to IgA nephropathy","volume":"123","author":"Huang HD","year":"2010","journal-title":"Chin. Med. J."},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2008.0810"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1086\/320104"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.07.010"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.06.013"},{"key":"e_1_2_8_91_1","first-page":"67","article-title":"Alteration by oral contraceptives of normal menstrual changes in plasma renin activity, concentration and substrate","volume":"36","author":"Skinner SL","year":"1969","journal-title":"Clin. Sci."},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000122875.91100.28"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.113"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.042002"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000410"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12098","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.12098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T18:28:59Z","timestamp":1746037739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,27]]},"references-count":94,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/1440-1681.12098"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12098","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"type":"print","value":"0305-1870"},{"type":"electronic","value":"1440-1681"}],"subject":[],"published":{"date-parts":[[2013,10,27]]}}}