{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:42:25Z","timestamp":1762144945202},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\n<jats:list>\n\n<jats:list-item><jats:p>Altered autonomic control of the cardiovascular system in chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) contributes to an increased risk of cardiovascular events. The aim of the present study was to determine whether and when autonomic dysfunction occurs in a conscious, telemetered, rodent model of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>In <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewis polycystic kidney (<jats:styled-content style=\"fixed-case\">LPK<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a08) and <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewis (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) rats, blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>), systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> variability (<jats:styled-content style=\"fixed-case\">SBPV<\/jats:styled-content>) and baroreflex sensitivity (<jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content>) were determined from 10 to 16\u00a0weeks of age.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The <jats:styled-content style=\"fixed-case\">LPK<\/jats:styled-content> rats had higher systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (average across all ages: 230\u00a0\u00b1\u00a010 <jats:italic>vs<\/jats:italic> 122.6\u00a0\u00b1\u00a00.3\u00a0mm<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>g; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.001), increased <jats:styled-content style=\"fixed-case\">SBPV<\/jats:styled-content> (average across all ages: 13.9\u00a0\u00b1\u00a01.9 <jats:italic>vs<\/jats:italic> 5.2\u00a0\u00b1 0.2\u00a0mm<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>g<jats:sup>2<\/jats:sup>; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.01) and reduced low\u2010frequency <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> power (average across all ages: 1.5\u00a0\u00b1\u00a00.3 <jats:italic>vs<\/jats:italic> 2.6\u00a0\u00b1\u00a00.2\u00a0msec<jats:sup>2<\/jats:sup>; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.05). Between 10 and 12\u00a0weeks of age, <jats:styled-content style=\"fixed-case\">SBPV<\/jats:styled-content> increased twofold in the <jats:styled-content style=\"fixed-case\">LPK<\/jats:styled-content> rat (8.13\u00a0\u00b1\u00a01.05 <jats:italic>vs<\/jats:italic> 16.10\u00a0\u00b1\u00a01.31\u00a0mmHg<jats:sup>2<\/jats:sup> for 10 <jats:italic>vs<\/jats:italic> 12\u00a0weeks of age, respectively; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.001), coinciding with an approximate 40% reduction in <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> (1.32\u00a0\u00b1\u00a00.14 <jats:italic>vs<\/jats:italic> 0.79\u00a0\u00b1\u00a00.11\u00a0ms\/mmHg for 10 <jats:italic>vs<\/jats:italic> 12\u00a0weeks of age, respectively; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.05). There was no difference in <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">LPK<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewis rats at 10\u00a0weeks of age; however, from 12\u00a0weeks onwards, <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> was reduced in <jats:styled-content style=\"fixed-case\">LPK<\/jats:styled-content> rats (0.75\u00a0\u00b1 0.01 <jats:italic>vs<\/jats:italic> 1.17\u00a0\u00b1\u00a00.04\u00a0ms\/mmHg; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Baroreceptor regulation of <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> becomes impaired between 10 and 12\u00a0weeks of age in the <jats:styled-content style=\"fixed-case\">LPK<\/jats:styled-content> rat, coinciding with an increase in <jats:styled-content style=\"fixed-case\">SBPV<\/jats:styled-content>. Preventing baroreflex dysfunction in <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> may reduce <jats:styled-content style=\"fixed-case\">SBPV<\/jats:styled-content> and the associated mortality risks.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/1440-1681.12110","type":"journal-article","created":{"date-parts":[[2013,5,11]],"date-time":"2013-05-11T11:12:49Z","timestamp":1368270769000},"page":"458-465","source":"Crossref","is-referenced-by-count":19,"title":["Temporal development of baroreceptor dysfunction in a rodent model of chronic kidney disease"],"prefix":"10.1111","volume":"40","author":[{"given":"Cara M","family":"Hildreth","sequence":"first","affiliation":[{"name":"Australian School of Advanced Medicine Macquarie University Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya Sarma","family":"Kandukuri","sequence":"additional","affiliation":[{"name":"Australian School of Advanced Medicine Macquarie University Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann K","family":"Goodchild","sequence":"additional","affiliation":[{"name":"Australian School of Advanced Medicine Macquarie University Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline K","family":"Phillips","sequence":"additional","affiliation":[{"name":"Australian School of Advanced Medicine Macquarie University Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-009-0056-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000098687.01005.A5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12112427"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000254377.18983.eb"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00452.2003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb26704.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04588.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/18.2.318"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.8.1976"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr340"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-393"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000101828"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.09.019"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01009.2007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-233-9_12"},{"key":"e_1_2_7_18_1","first-page":"F391","article-title":"Continuous telemetric blood pressure monitoring and glomerular injury in the rat remnant kidney model","volume":"265","author":"Bidani AK","year":"1993","journal-title":"Am. 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