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The genes encoding the three <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> subunits are likewise important contributors to hypertension, both in rare monogenic diseases and in the general population.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The unusually high numbers of genetic variants associated with complex traits, including <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, that are located in non\u2010coding areas suggest an involvement of these variants in regulatory functions. This may involve differential regulation of expression in different tissues.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Emerging evidence indicates that the <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> plays an important role in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> determination not only via its actions in the kidney, but also in other tissues commonly involved in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> regulation. The <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> in the central nervous system is proposed to regulate <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> via sympathetic nervous system activity. Recent evidence suggests that the <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> contributes to vascular function and the myogenic response. Additional roles potentially include initiation of the baroreceptor reflex via <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> in the baroreceptors and driving high salt intake with a \u2018taste for salt\u2019 via <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> in the tongue.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The present review describes the involvement of the <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> in the determination of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> at a genetic and physiological level, detailing recent evidence for its role in the kidney and in other pertinent tissues.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/1440-1681.12124","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T16:11:58Z","timestamp":1369411918000},"page":"495-503","source":"Crossref","is-referenced-by-count":26,"title":["Blood pressure regulation via the epithelial sodium channel: From gene to kidney and beyond"],"prefix":"10.1111","volume":"40","author":[{"given":"Cara J","family":"B\u00fcsst","sequence":"first","affiliation":[{"name":"Departments of Physiology The University of Melbourne and Monash University Melbourne Vic. 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